S100A9

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S100A9

A gene on chromosome 1q21 that encodes a member of the S100 family of proteins, which contain 2 EF-hand calcium-binding motifs and as a group regulate cell cycle progression and differentiation and other cellular processes. S100A9 has antimicrobial activity against bacteria and fungi and provides resistance to invasion by pathogenic bacteria, and it upregulates transcription of genes under the control of NF-kappa-B; it is linked to the endotoxic shock response to bacterial lipopolysaccharide. S100A9 promotes tubulin polymerisation and macrophage and granulocyte migration and infiltration into wound sites; it is a pro-inflammatory mediator and upregulates IL8 release and cell surface expression of ICAM1. Extracellular S100A9 (calprotectin) binds to target cells and promotes apoptosis.
 
Molecular pathology
Altered expression of S100A9 is linked to cystic fibrosis.
References in periodicals archive ?
Address : Numro National D~identification : Cagb 4 Rue Gabriel Planon 25043 Besanon F
Main features: supply and installation of games for children from 3 to 11 years, as part of the development by the cagb of a playground on the basis of multi-activity leisure osselle - routelle form of market: ordinary.
Main features: supply, installation and connection of the photovoltaic system in the shade in the personal parking of the besanon tramway maintenance center (cagb building), located route de franois in besanon.
to all these contracts, the contract must be added automobile fleet insurance for the city, ccas, cagb, isba, epcc les deux scnes, rodia and sybert.
Main features: Under the new territorial organization of the republic (notre) act, the water and sanitation powers are transferred from the municipalities and their unions to the agglomeration community of grand besanon (cagb) since 1 january 2018.
- all municipalities in the geographical area of cagb 25000 besancon
Verification and maintenance of existing natural smoke extraction equipment and equipment in the establishments managed by the city of besancon and the cagb: - periodic preventative maintenance operations, in compliance with the regulations in force, - corrective maintenance operations, - special verification services and maintenance to be carried out on the express request of the owner.
The cagb grants to the holder of the market the exclusive right to exploit the advertising media on the urban vehicles of the ginko public transport network of the greater besanon urban community, which it owns or which would be entrusted to it during the period of the market