CACNG4

CACNG4

A gene on chromosome 17q24 that encodes a gamma subunit of a voltage-dependent calcium channel, which regulates AMPA-selective glutamate receptor (AMPAR) trafficking and gating. It promotes
AMPAR targeting to the cell membrane and synapses, and it modulates their gating properties by slowing their activation, deactivation and desensitisation and by mediating their resensitisation.
References in periodicals archive ?
Expression of Cacna1d (3-fold), Cacna1g, Cacna1h (4-fold), Cacna2d1, Cacna2d3, and Cacng4 (3-fold) were downregulated in GK compared to control SAN.
Regarding the changes in mRNA of particular interest were (i) downregulation of Gja5 and Gjd3 (4-fold), (ii) downregulation of Trpc6 (6-fold), (iii) downregulation of Hcn4 (5-fold), (iv) downregulation of Cacna1d (3-fold), Cacna1h (4-fold), and Cacng4 (3-fold), (v) downregulation of Kcna5 (5-fold) and Kcnk1 (7-fold) in GK compared to control SAN, and (vi) upregulation of Nppb in GK compared to control SAN.
Cacna1d ([Ca.sub.v]1.3), Cacna1h (Cav3.2), and Cacng4 ([Cav.sub.[gamma]]4) were downregulated in GK compared to control SAN.
En la segunda fase, con las 27 proteinas extraidas (NTRK1, ELAVL1, RAB5A, GTSE1, OCRL, NXF1, GRB2, CLTC, RAB8A, RAB1A, RAB6A, SSX2IP, XPO1, FAM109A, FAM109B, SPINT2, GOLGA5, CEP128, SCLT1, CEP170, HERC2, SCN2B, ENPP6, VSIG4, BTN2A1, CACNG4, RAB14), se construyo una red de interaccion en el Software Cytoscape version 3.3.0 (Shannon, et al., 2003).