CACNA2D3

CACNA2D3

A gene on chromosome 3p21.1 that encodes the alpha-2D3 subunit of a voltage-dependent calcium channel, which regulates calcium current density and activation/inactivation kinetics of the calcium channel, and which plays an important role in excitation-contraction coupling. CACNA2D3 acts as a regulatory subunit for P/Q-type (CACNA1A), N-type (CACNA1B), L-type (CACNA1C or CACNA1D), but not T-type (CACNA1G) calcium channels.
References in periodicals archive ?
Expression of Cacna1d (3-fold), Cacna1g, Cacna1h (4-fold), Cacna2d1, Cacna2d3, and Cacng4 (3-fold) were downregulated in GK compared to control SAN.
However, there were only two differentially expressed genes (CACNA2D3 and PPM1B) in the MAPK pathway and one key gene (TLR6) in the TLR pathway in the AS group cultured in normal media, both with an insignificant KEGG analysis score (P > 0.05).
Group KEGG pathway ID and name Count of Percent of compared genes count of genes Normal Hsa04010: MAPK signaling 2 0.30% environment pathway Hsa04620: toll-like receptor 1 0.15% signaling pathway Inflammatory Hsa04010: MAPK signaling 14 0.79% environment pathway Group Gene name P value compared Normal CACNA2D3, PPM1B 0.12000 environment TLR6 0.20000 Inflammatory GNA12, DUSP1, MAPK11, RAC1, environment MRAS, ELK1, ATF4, MAPK3, 0.00000 CDC25B, STMN1, MAX, TGFBR2, CACNB3, FGF8, and RASA2 TABLE 5: Key gene list of signaling pathways related to AS.