CACNA1E

CACNA1E

A gene on chromosome 1q25-q31 that encodes the alpha-1E subunit of a voltage-dependent calcium channel, which mediates the entry of calcium ions into excitable cells. These channels are also involved in various calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and apoptosis. CACNA1E gives rise to R-type calcium channels that belong to the high-voltage activated (HVA) group, which may be involved in modulating firing patterns of neurons important for information processing.
References in periodicals archive ?
Differential regulation of glutamate receptor ionotropic, kainate 3 (GRIK3) and voltage-dependent R-type calcium channel subunit alpha-IE (CACNA1E) in frontal cortex datasets may be biologically relevant with the mentioned pathways in AD brain areas.
In our study, differential regulation of glutamate receptor ionotropic, kainate 3 (GRIK3) and voltage-dependent R-type calcium channel subunit alpha-IE (CACNA1E) in frontal cortex datasets could be therefore biologically relevant with the mentioned pathways in AD brain areas.
The [[alpha].sub.1] subunit isoforms include A, B, C, D, E, and G, encoded by CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, and CACNA1G genes, respectively.