CACNA1EA gene on chromosome 1q25-q31 that encodes the alpha-1E subunit of a voltage-dependent calcium channel, which mediates the entry of calcium ions into excitable cells. These channels are also involved in various calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and apoptosis. CACNA1E gives rise to R-type calcium channels that belong to the high-voltage activated (HVA) group, which may be involved in modulating firing patterns of neurons important for information processing.
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