CACNA1D

A gene on chromosome 3p14.3 that encodes the alpha-1D subunit of a voltage-dependent L-type calcium channel, which mediates the entry of calcium ions into excitable cells. These channels are also involved in various calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and apoptosis. CACNA1D gives rise to L-type calcium channels which belong to the high-voltage activated (HVA) group.

Mentioned in ?

References in periodicals archive ?

CalbindinD28k, NM_031984.1, UPL Probe #128 (Roche 04693647001); Parvalbumin, NM_022499.1, UPL Probe #49 (Roche 04688104001); Grin1 NM_001270602.1 UPL Probe #69 (Roche 04688686001); Grin2a NM_012573.3 UPL Probe #66 (Roche 04688651001); Grin2b NM_012574.1 UPL Probe # 29 (Roche 04687612001); Grin2c NM_012575.3 UPL Probe #106 (Roche 04692250001); Grin2d NM_022797.1 UPL Probe #4 (Roche 04685016001); Grin3a NM_001198583.1 UPL Probe #105 (Roche 04692241001) CACNA1C, NM_012517.2, UPL Probe #73 (Roche 04688961001); CACNA1D, NM_017298.1, UPL Probe #82 (Roche 04689054001).

The Role of Astaxanthin on Transcriptional Regulation of NMDA Receptors Voltage Sensitive Calcium Channels and Calcium Binding Proteins in Primary Cortical Neurons

A few important genes included in this list are OXT, GRIN1, CHAT, and CACNA1D which are potential regulators of neurophysiological processes and have a high degree of implication in psychological disorders.

The Effect of Citalopram on Genome-Wide DNA Methylation of Human Cells

Expression of Cacna1d (3-fold), Cacna1g, Cacna1h (4-fold), Cacna2d1, Cacna2d3, and Cacng4 (3-fold) were downregulated in GK compared to control SAN.

The Pattern of mRNA Expression Is Changed in Sinoatrial Node from Goto-Kakizaki Type 2 Diabetic Rat Heart

Bidirectional Sanger sequencing was performed for targeted mutation detection in the KCNJ5, ATP1A1, ATP2B3, CACNA1D, CACNA1H, and PRKACA genes using DNA extracted from the tumor tissues of the 22 A/CPA patients.

Clinical Characteristics of Aldosterone- and Cortisol-Coproducing Adrenal Adenoma in Primary Aldosteronism

k) Mutations in CACNA1D and CHI (Single Case Report)

Congenital Hyperinsulinism: Diagnosis and Treatment Update

3 regulates insulin release and polymorphisms in CACNA1D associate with type 2 diabetes.

Influence of cross-disorder analyses on the diagnostic criteria of mental illnesses

This work then led to the discovery of various plasma membrane channel mutations [sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1), plasma membrane calcium-transporting ATPase 3 (ATP2B3), and voltage-dependent calcium channel type L alpha 1D subunit (CACNA1D)] in other APAs.

A Renin-ssance in primary aldosteronism testing: obstacles and opportunities for screening, diagnosis, and management

During the past 2 years, considerable interest has been generated by the discovery of sporadic mutations in potassium channels (KCNJ5), calcium channels (CACNA1D), and ATPases (ATP1A1 and ATP2B3; Figure 2, C).

Clinicopathologic Correlates of Primary Aldosteronism

Loss of Cav1.3 (CACNA1D) function in a human channelopathy with bradycardia and congenital deafness.

Immunolocalization of a voltage-gated calcium Channel [beta] Subunit in the tentacles and cnidocytes of the Portuguese man-of-war, Physalia physalis

hydronephrosis Imipramine ADRA18, ADRA1D Renal nephritis Imipramine TP53, NOS1, CTNS, ALB, NFKB2, VDR, PDE4D, PPP3CA, ACE Heart failure lmipramine EPO, NOS1, ATP1A3, CACNA1D, ACCN3, KCNG2, PDE4D, SLC9A1, TTN, ADRB3, KCNJ11, ADRA1D.

Prediction of adverse events by in vivo gene expression profiling exemplified for phytopharmaceuticals containing salicylates and the antidepressant imipramine

Mendelian forms of hypertension and germline mutations causing early-onset hypertension have highlighted biological pathways that involve renal salt handling (WNK1, WNK4, KLHL3, and CUL3), ion transport (CACNA1D, CACNA1H, KCNJ5, SCNN1B, and SCNN1G), corticosteroidogenesis (CYP11B2, HSD11B2, NR3C2, CYP11B1, and CYP17A1), and vascular tone (PDE3A) to regulate blood [41-44].

Brief Overview of a Decade of Genome-Wide Association Studies on Primary Hypertension

For example, clinical studies have demonstrated overexpression of CACNA1D ([Ca.sub.v]1.3) (L type), CACNA1A ([Ca.sub.v]2.1) (P/Q type), and CACNA1G ([Ca.sub.v]3.1) (T type) in lung cancer, and overexpression of CACNA1A ([Ca.sub.v]2.1) was associated with poor prognosis [15].

CACNA1B ([Ca.sub.v]2.2) Overexpression and Its Association with Clinicopathologic Characteristics and Unfavorable Prognosis in Non-Small Cell Lung Cancer

Full browser ?

CITE

Site: Follow: Share:

Open / Close