CACNA1B

CACNA1B

A gene on chromosome 9q34 that encodes the alpha-1B subunit of a voltage-dependent N-type calcium channel, which mediates the entry of calcium ions into excitable cells. These channels are also involved in various calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and apoptosis. CACNA1B is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons.
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The [[alpha].sub.1] subunit isoforms include A, B, C, D, E, and G, encoded by CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, and CACNA1G genes, respectively.
Among those genes were CACNA1B and DOC2A, both of which carry the codes for proteins that use calcium signals to help control how neurotransmitters are released in the brain.
CACNA1B ([Ca.sub.v]2.2) is the only member in N-type VGCC family, and CACNA1B ([Ca.sub.v]2.2) overexpression has been detected in breast and prostate cancer [15], and it represents a novel therapeutic target for the treatment of breast and prostate cancer.
In the current study, we determined both mRNA and protein expression of CACNA1B ([Ca.sub.v]2.2) in NSCLC tissue samples by quantitative reverse transcription PCR (qRT-PCR) and tissue microarray immunohistochemistry analysis (TMA-IHC), respectively, and correlated to patients' clinical characteristics and overall survival.
CACNA1B ([Ca.sub.v]2.2) mRNA and Protein Expression and Statistical Analysis.
Student's t-test was used to compare CACNA1B ([Ca.sub.v]2.2) mRNA and protein expression between tumorous and nontumorous tissue samples.
CACNA1B ([Ca.sub.v]2.2) mRNA Level Was Significantly Higher in NSCLC Tumorous Tissues than in Adjacent Nontumorous Tissues.
CACNA1B ([Ca.sub.v]2.2) Protein Level Was Significantly Higher in NSCLC Tumorous Tissues than in Adjacent Nontumorous Tissues.
Association of CACNA1B ([Ca.sub.v]2.2) Expression with NSCLC Clinical Characteristics.
High CACNA1B ([Ca.sub.v]2.2) Expression Predicts Poor Overall Survival in NSCLC Patients.
In the current study, we determined mRNA and protein expression levels of CACNA1B ([Ca.sub.v]2.2) in both NSCLC tumorous and adjacent nontumorous tissues.
CACNA1B ([Ca.sub.v]2.2) is an N-type VGCC and expressed in the brain and the peripheral nervous system.