CACNB4

(redirected from CAB4)

CACNB4

A gene on chromosome 2q22-q23 that encodes a beta subunit of a voltage-dependent calcium channel, which plays a regulatory role in calcium channel function by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling alpha-1 subunit membrane targeting.

Molecular pathology
CACNB4 mutations have been associated with idiopathic generalised epilepsy and juvenile myoclonic epilepsy.
References in periodicals archive ?
The input current is injected to the CAB2, while the output signal is taken from [I.sub.o-dw] of the CAB4. The resistor [R.sub.2k-1] in CAB2 implements the source resistance and [R.sub.2k-1] in CAB4 the termination of the ladder.
CAB switch configuration for the first filter example [K.sub.C2k] [K.sub.R2k-1] [K.sub.R2k] CAB1 CAB2 ON ON CAB3 ON CAB4 ON [K.sub.fb] Output CAB1 CAB2 CAB3 CAB4 [I.sub.o-dw] Table 4.