- Combination of sTRA and CA19-9
Test to Detect Pancreatic Cancer Biomarkers
According to the company, the results demonstrated that the IMMray PanCan-d signature together with CA19-9
generated ROC AUC-values of 0.97, 0.98 and 0.96 when differentiating PDAC (pancreatic cancer) vs non-PDAC symptomatic individuals, healthy controls and type II diabetes, respectively.
In addition, the CA19-9
levels dropped 94% from levels prior to this line of therapy.
While the mean CA19-9
value before RT was 53.2[+ or -]115.4 (median, 16.1), it was 17.5[+ or -]32.1 (median, 7.0) in the 5th week after RT.
Laboratory test results were as follows: CA125: 82 U/mL, CA19-9
: 42 U/mL, and glycated hemoglobin (HbA1c): 11%.
During the preoperative period, the mean levels of CA 125, CEA, CA19-9
and CA 15-3 in all study patients were 63.19[+ or -]93.8 U/mL (range 3.09-394 U/mL), 31.29[+ or -]76.63 U/mL, 20.83[+ or -]11.24 U/mL (range 6.40-48.60 U/mL) and 2.32[+ or -]2.09 ng/mL (range 0.50-10.8 ng/mL), respectively.
Immunohistochemical staining were carried out on the cell block and core biopsy sections using antibodies to thyroid transcriptor factor-1 (TTF-1), Napsin-A, Thyroglobulin, CD10, PAX 8, AMACR, CA19-9
and CD57 (Automated Ventana Bench Mark machine, the EnVisionTm System).
Hastanin hemogram, biyokimya ve serum tumor belirtecleri (CA125, CA 15-3, CA19-9
,10, CEA) normal duzeylerdeydi.
level > 129 U/L in the setting of a biliary mass is highly suggestive of cholangiocarcinoma.
Tumor markers including Alpha Fetoprotein, CEA and CA19-9
were also normal.
In the case of CA19-9
, this limited utility may reflect the fact that this biomarker is not expressed in some patients, and in others it may be increased for reasons unrelated to PDAC, such as biliary infections and inflammatory processes (6).
Laboratory examination showed elevated carbohydrate antigen 125 (CA125) level, 280.7 IU/ml, and normal CA19-9
and carcinoembryonic antigen (CEA) level.