MUC16

(redirected from CA125)

MUC16

A gene on chromosome 19p13.2 which encodes a protein that provides a protective lubricating barrier against particles and infectious agents at mucosal surfaces. It is more commonly known as CA125, and is a highly characteristic marker of ovarian carcinomas.
References in periodicals archive ?
Patients with endometriosis were more likely to gain moderate-to-severe dysmenorrhea (visual analogue scale [VAS] ≥4) and high level of CA125 by comparison with controls ( Z = −2.
Role of CA125 in predicting ovarian cancer survival-a review of the epidemiological literature.
13) that is designed to bind to the tumor associated antigen CA125 (also designated MUC16) and initiate a cascade of immune responses against this glycoprotein.
The level of CA125 was detected using electrochemiluminescence assay (ELISA).
CA125 levels were raised and a second look ultrasound scan revealed a viable fetus with a right-sided ovarian mass.
Moreover, the elevated CA125 was another misleading factor that increased our suspicion of ovarian mass.
The trial, which was conducted at 42 sites across the UK, saw researchers take participants' blood in order to monitor levels of a chemical called CA125 three times a year.
Most of the time there is a simple explanation for your symptoms but better to be safe than sorry especially as these days a new simple blood test is available to test for ovarian cancer, it detects the protein CA125 levels in your blood which is an indicator of ovarian cancer.
Officials with the American Congress of Obstetricians and Gynecologists echoed the FDA's concern, pointing out that several ovarian cancer screening tests, including the CA125 test and the Risk of Ovarian Cancer Algorithm test, are currently available and claim to detect ovarian cancer before symptoms occur.
However, increased circulating CA125 is also found in patients suffering from endometriosis, liver disease, and ovarian cysts (2).
Al terminar el 3 o 4 ciclo de quimioterapia se debe realizar evaluacion clinica e imagenologica y CA125 si este ha estado elevado previamente, con el fin de decidir la cirugia de intervalo.