MUC16

(redirected from CA125)

MUC16

A gene on chromosome 19p13.2 which encodes a protein that provides a protective lubricating barrier against particles and infectious agents at mucosal surfaces. It is more commonly known as CA125, and is a highly characteristic marker of ovarian carcinomas.
References in periodicals archive ?
M2 PHARMA-July 17, 2019-Verm Publishes New Study Demonstrating Overa's Greater Sensitivity in Detecting Ovarian Cancer Compared with ROMA, HE4 + CA125, and CA125 Alone
The study of 993 patients with 245 malignancies shows that Vermillion's second generation multivariate index assay, Overa, had superior sensitivity to the current standards of care, Risk of Malignancy Algorithm, or ROMA, and CA125, in detecting ovarian cancer, and the lowest false-negative rate in correctly characterizing ovarian malignancy risk.
(1) Another important clue that HCO is a surface epithelial tumor is the fact that most patients show elevated levels of circulating cancer antigen 125 (CA125), and expression of CA125 antigen by immunohistochemistry.
Evaluation of Serum CEA, CA19-9, CA72-4, CA125 and ferritin as diagnostic markers and factors of clinical parameters for colorectal cancer.
Among the patients with CA125 levels >35 U/ml, 51 (92.73%) had malignancy and 10 (12.99%) benign tumour with a p value 0.0001.
"For women with an elevated risk of ovarian cancer, screening with pelvic ultrasound and a blood test for a tumor marker called CA125 may be considered.
The data used to analyze the potential predictors for therapeutic response were collected retrospectively, including age, T2 signal intensity ratio (T2SR), contrast-enhanced T1 signal intensity ratio (T1*SR), junctional zone-to-myometrial ratio (JZ-Myo ratio), serum cancer antigen 125 (CA125) level, uterine volume, morphological type, location, dysmenorrhea, menorrhagia, accompanying endometriosis, and accompanying leiomyoma.
There was no correlation between recurrence and the following factors including patient's age, menarche age, gravidity, parity, CA125 level, ovarian lesions, menopausal status, combined benign gynecological conditions (such as myoma and adenomyoma) and endometrial abnormalities, and surgical approach or surgical staging (all P > 0.05).
Her laboratory investigations were all within the normal limits apart from high levels of cancer cell surface antigen 125 (CA125) of 576 IU/l.
If your bloating carries on for more than three weeks, ask your GP for a CA125 blood test, which detects levels of a protein that may indicate ovarian cancer.