CA1


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CA1

A gene on chromosome 8q21.2 that encodes a carbonic anhydrase, a zinc metalloenzyme that catalyses the reversible hydration of carbon dioxide. Carbonic anhydrases participate various biological processes, including respiration, calcification, maintaining acid-base balance, bone resorption and producing aqueous humour, cerebrospinal fluid, saliva and gastric acid. CA1 is a cytosolic protein highly expressed in erythrocytes.
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The objective of our study was to investigate the potential role of the hippocampus, particularly the CA1 area, in tinnitus, to provide electrophysiological evidence for the pathogenesis of tinnitus.
Information processed by the dentate gyrus gets passed along to the CA3, and then on to CA1. In other words, the CA1 and CA3 should carry out the same function because they're both part of the same information processing circuit.
We further compared the expression changes of PICK-1 and PSD-95 in the subregion of the hippocampus (DG, CA3, and CA1) with immunohistochemistry and semiquantitative measurement by optic density.
On assessing the hippocampal activity of the mice, the researchers found that rodents that had sufficient sleep after the learning task demonstrated stronger sleep-related oscillations in the CA1 region of the hippocampus, compared with sleep-deprived mice.
RT-PCR was performed to investigate the effects of LA on the mRNA expressions of Creb, Bdnf, Bcl2, and Bax in the hippocampal CA1 region of MCAO rats (Figure 6).
However, the trends were similar: a moderate decrease was found in the number of PV-positive interneurons in the dentate gyrus, the CA1, CA2, and CA3 regions of patients with no sclerosis [17, 25].
In brief, two recording tetrodes were implanted in the MDT of thalamus (with bregma as the reference, anteroposterior (AP), -1.2 mm; mediolateral (ML), -0.6 mm; dorsoventral (DV), -3.1mm) and the CA1 of right hippocampus (AP, -1.2 mm; ML, -0.6 mm; DV, -1.7 mm), and one stimulation bipolar electrode was implanted in the right basolateral amygdala (BLA, AP, -1.2 mm; ML, -2.6 mm; DV, -4.9 mm).
The stratum oriens was not included in the counts to be the outermost layer of the CA1 hippocampus, where the reactions end up in shrunken anamorphic tissue (edge effect) with very intense background.
In the control group, pyramidal cells in the CA1, CA3 and CA4 regions were densely arranged, and had longer processes and were deeply stained.