CA.1bc.12A gene on chromosome 15q22 that encodes a carbonic anhydrase, a zinc metalloenzyme that catalyses the reversible hydration of carbon dioxide. Carbonic anhydrases participate in various biological processes, including respiration, calcification, maintaining acid-base balance and bone resorption, as well as producing aqueous humour, cerebrospinal fluid, saliva and gastric acid. The CA12 product is a type-I membrane protein which is highly expressed in normal tissues, such as the kidneys, colon and pancreas.
CA12 is overexpressed in 10% of clear-cell carcinomas of the kidney.
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