CA2

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CA2

A gene on chromosome 8q22 that encodes an isoenzyme of carbonic anhydrase, a zinc metalloenzyme that catalyses the reversible hydration of carbon dioxide. Carbonic anhydrase 2 is essential for bone resorption and osteoclast differentiation.

Molecular pathology
CA2 mutations are associated with osteopetrosis and renal tubular acidosis.
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References in periodicals archive ?
In the southern portion of CA-II that is dominated by sandy substrate, sponges are one of the microhabitats whose abundance differs significantly between fished and unfished areas (Lindholm et al., 2004) as was also recorded in our study.
Depth has also been shown to influence the abundance and biomass of other benthic taxa (i.e., amphipods and the brittle star Ophiura robusta) in the southern portion of CA-II (Link et al., 2005).
increased in abundance inside CA-II. The increased density of P.
droebachiensis may have also benefited from the elevated cover of colonial epifauna in CA-II because this species is known to eat sponges, hydroids, bryozoans, tunicates, and amphipod and polychaete tube complexes at locations where macroalgae and kelp (the preferred diet of sea urchins) are absent (Briscoe and Sebens, 1988).
After the establishment of CA-II, several colonial and noncolonial taxa underwent successive increases and declines in abundance at site 17, thus, providing potential evidence of ecological succession.
At the 50-m site on Cashes Ledge, which is the most comparable to our study area in CA-II, I.
Mean CA-II autoantibody levels in the same groups were 0.253[plus or minus]0.174, 0.155[plus or minus]0.137, and 0.131[plus or minus]0.085 ABSU (p=0.005) (Figure 1).
A weak correlation was detected between diabetic patients' HbA1c and CA-II autoantibody levels (r=0.36, p=0.027).
Mean CA-I autoantibody levels of all diabetic patients in the study (n=37) and the healthy subjects in group 3 (n=38) were 0.13[plus or minus]0.06 and 0.138[plus or minus]0.061 ABSU, respectively; mean CA-II autoantibody levels in the same groups were 0.2[plus or minus]0.161 and 0.131[plus or minus]0.085 ABSU.
In both of the studies, CA-II autoantibody levels were measured in type 1 and 2 diabetes patients, and CA-II autoantibody levels were higher in patients with type 1 diabetes compared to those with type 2 diabetes.
In our study, the increase in CA-II autoantibody levels in type 1 diabetes patients was more pronounced in the presence of DRP.
There are no previous studies in the literature examining the relationship between serum CA-I and CA-II levels and the development of DRP in patients with type 1 diabetes.