CA-125

(redirected from CA-125 test)

CA-125

Abbreviation for cancer antigen 125 and the test for it. See: cancer antigen 125 test.
Farlex Partner Medical Dictionary © Farlex 2012

MUC16

A gene on chromosome 19p13.2 which encodes a protein that provides a protective lubricating barrier against particles and infectious agents at mucosal surfaces. It is more commonly known as CA125, and is a highly characteristic marker of ovarian carcinomas.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

CA-125

A cell surface glycoprotein expressed on the cell membrane of normal ovarian tissue, ovarian, cervical, endometrium, GI tract, and breast CAs; rising levels indicate a poor prognosis, but low levels are of little clinical utility; CA-125 may also be ↑ in liver disease, acute pancreatitis, renal failure, occasionally in normal ♀, lymphoma
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
As for the CA-125 test, levels of this marker can be elevated for other reasons, including many benign gynecologic conditions.
We have tested this possibility by combining the MALDI-TOF MS analysis of serum glycans with CA-125 test, and such combination with CA-125 cut-off 35U/mL significantly enhanced the sensitivity of the results (~15%, data not shown) when a sample was categorized as a patient's sample either by the serum glycan profiling or by CA-125 test.
Unfortunately the CA-125 test has not proven effective for ovarian cancer screening in asymptomatic women.
In reaching its decision, the USPSTF reviewed studies that have been conducted since its earlier recommendation and found that ovarian cancer screening using transvaginal ultrasound and a CA-125 test (see box) doesn't reduce the number of deaths from the disease.
Some physicians will use a CA-125 test to decide whether surgery should be done by a gynecologic oncologist or, if CA-125 levels were high before surgery, as a follow-up to see how well treatment is working.
The CA-125 test is often elevated in ovarian cancer, a finding that led to considering use of the test for ovarian cancer screening.
3) The CA-125 test only returns a true positive result for about 50% of Stage I ovarian cancer patients.
Anderson Cancer Center discovered a new way to use the cancer antigen or CA-125 test, which measures levels of a protein that is elevated in ovarian cancer cells.
But don't bet your life on this when the CA-125 test is so readily available.
The disadvantages of using the CA-125 test as a screening tool are its lack of specificity and its inability to detect early cancers.
"Questions and answers about the CA-125 test." Johns Hopkins Pathology.
The most commonly used test, the CA-125 test, detects levels of a protein on the surface of many cancer cells.