GPR77

(redirected from C5L2)

GPR77

A gene on chromosome 19q13.33 that encodes a G protein-coupled receptor for the chemotactic and inflammatory peptide anaphylatoxins C5a, C4a and C3a and their derivatives.
References in periodicals archive ?
The C5-like receptor 2 (C5L2) is postulated to be a unique ASP receptor, although some studies found no interaction between C5L2 and ASP (19, 25).
In addition, abnormal keratinocyte proliferation is a characteristic of psoriasis, and the lack of C5L2 expression on epidermal keratinocytes may explain the low ASP level in the patient group.
C5a- and ASP-mediated C5L2 activation, endocytosis and recycling are lost in S323I-C5L2 mutation.
It was revealed that septic patients had low expression levels of C5aR and C5L2 on neutrophils compared to healthy and SIRS cases, and this expression pattern was correlated with disease severity.