ADAMTSab1

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ADAMTSab1

An ADAMTS family protease encoded by ADAMTS1 on chromosome 21q21.2, which is antiangiogenic (ADAMTS1 disrupts angiogenesis in vivo and in vitro more efficiently than ADAMTS8, thrombospondin-1, or endostatin). ADAMTS1 is associated with acute inflammation and various inflammatory processes and with the development of cancer cachexia. ADAMTS1 expression is induced by IL1 and appears to be necessary for normal growth, fertility (it is up-regulated by progesterone during ovulation, and may play a critical role in follicular rupture), organogenesis and organ function. ADAMTS1 activity is blocked by some metalloprotease inhibitors, including TIMP-2 and TIMP-3. Thrombospondin proteolysis is decreased or absent in ADAMTS1 knock-out mice and associated with delayed wound closure and increased angiogenesis.
References in periodicals archive ?
It revealed a well-defined cystic lesion at posterior aspect of neck on right side at the level of C3-C5 vertebrae, with the possibility of the lesion being hydatid cyst (Figure 1).
MRI of Head and Neck Region showing Well-defined Cystic Lesion at Posterior Aspect of Neck on Right side at the Level of C3-C5 Vertebrae
The surgery was performed with a metal plate and screws bridging C3-C5.
The second most insignificant difference pairs in term of mean values were C3-C5 pair for rectangular aspect ratio and minor axis length and C2-C4 pair for minor axis length and aspect ratio.
We've had to increase the mud weights considerably as we drill deeper, and we continue to see rising mudlog gas readings, including the oil-indicative C3-C5 factions, which is encouraging.
Sensilas de la clava: sensilas basiconicas alargadas subfusiformes (Figura 1c) localizadas en o proximas al margen apical de todos los segmentos, como en Adryas breviterebratum Viggiani y Velasquez (2006); sensilas placoideas C2-C5 con 1, 1, 3, 3; sensilas trichoideas C1-C3 con 1, 1, 1 respectivamente; C3-C5 con varias setas flagelares y C5 con varias sensilas recurvadas sobre la superficie ventroapical, como en Adryas spp.
The buckling deformity, seen from C3-C5 with ventral spinal cord compression, was most severe at the C4 level.