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C3A diagnostic category based on the NHSBSP guidelines for reporting FNAC (fine needle aspiration cytology) of breast lesions. C3s have most of the characteristics described in C2s, but also have features not usually present in benign smears and have one or more of the following features:
(1) Crowded, enlarged nuclei with overlapping in three-dimensional groups or sheets;
(2) Loss of cellular cohesion;
(3) Nuclear pleomorphism;
(4) Chromatin clumping.
C3 cellularity may be normal or increased and large bare nuclei may be seen, as well as nuclear pleomorphism and dissociation.
Epithelial hyperplasia with or without atypia, fibroadenoma/fibroadenomatoid change, gynaecomastia, papilloma, hormonal changes, radial scar, atypical apocrine lesion, columnar cell change, lobular lesions (e.g., atypical lobular hyperplasi), certain carcinomas (e.g., tubular carcinoma, cribriform carcinoma).
complement deficiencyA state in which any of the complement proteins is subnormal
Complement deficiencies–associated disorders
C1r SLE, renal disease, repeated infections
C2 SLE, vasculitis, membranoproliferative glomerulonephritis, dermatomyositis
C3 Repeated infections
C5 SLE, gonococcal disease
C6 Relapsing meningococcal meningitis, gonococcal infection
C7 Raynaud's disease, chronic renal disease, gonococcal infection
C8 SLE, gonococcal infection