complement deficiency

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complement deficiency

A state in which any of the complement proteins is subnormal
Complement deficiencies–associated disorders
C1
C1r    SLE, renal disease, repeated infections
C1s    SLE
C2    SLE, vasculitis, membranoproliferative glomerulonephritis, dermatomyositis
C3 Repeated infections
C4 SLE
C5 SLE, gonococcal disease
C6 Relapsing meningococcal meningitis, gonococcal infection
C7 Raynaud's disease, chronic renal disease, gonococcal infection
C8 SLE, gonococcal infection
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
C1q protein is the recognition subcomponent of the C1 complex, which is composed of one molecule of C1q, two molecules of C1r, and two molecules of C1s ([C1qr.sup.2][s.sup.2]).
It regulates not only the Complement cascade (inhibitor of C1r, C1s, and MASPs) but is also an important regulator of the coagulation cascade activation and inhibits several fibrinolytic proteins (kallikrein, FXIIa, FXIa, and plasmin) [52].
(51) Culpeper, Pharmacopoeia londinensis, or The London dispensatory (London, 1653), C1r.
Complement C1r (C1R) gene methylation, which encodes a protein that is involved in the complement system, has been shown to be a robust, simple, and cost-effective biomarker for prognosis investigation in 194 AML patients.
In Pericles Gower introduces the first dumb show saying, "But tidinges to the contrarie, / Are brought your eyes, what need speake I" (C1r), which suggests he does not speak during the ensuing silent action.
C1r, and Henry Wilkinson, The Debt Book (London 1625), esp.
Forming cups with C1R instead of PEI also resulted in a 10 percent increase in cup weight.
C1R: Incumbent's protection ratio for co-channel and adjacent channel in dB [h.sub.1], [h.sub.2]: RCAMSL of antennas in m
We also identified genes that had not been previously correlated with breast cancer, including TERF2IP, which is involved in telomere regulation [53], IGSF1, which is involved in intracellular adhesion and transcription and is a signal transduction regulator [54], NMT2, which acts in the protein myristoylation process [55], FAD104, which positively regulates fat cell differentiation [56], PCM1, involved in centromere amplification and genomic instability [57], VWF, involved in cellular adhesion [58], C1R, which is involved in immune response and complement system activation [59], and POF1B, which binds nonmuscle actin filaments [60].
Complement system contains several serine proteases such as C1r, C1s, C3 convertase and C5 convertase.
C1 esterase inhibitor is known to carry out several important biochemical reactions in plasma, including inhibition of complement (C1r, C1s) and coagulation (Factor 12) pathways.