SERPING1

(redirected from C1NH)

SERPING1

A gene on chromosome 11q12-q13.1 that encodes a highly glycosylated plasma protein which regulates the complement cascade by inhibiting activated C1r and C1s, thereby preventing complement activation.

Molecular pathology
C1-INH/SERPING1 deficiency is associated with hereditary angioneurotic oedema (HANE).
References in periodicals archive ?
3] Mutations of non-European origin in C1NH gene in HAE patients have been reported in 15 patients of 4 unrelated Arab families in Middle East.
Novel and recurrent mutations in the C1NH gene of Arab patients affected with hereditary angioedema.
The bradykinin receptor B2R-9 allele has higher affinity for bradykinin and was associated with more severe episodes in cases of hereditary AE due to C1NH deficiency (9).