posadasii is largely found in Arizona, Texas, Mexico, and Central and South America; and C. immitis
is primarily found in central and southern California.
Usually C. immitis
grows 5-30 cm under the ground, especially around burrows of rodents and reptiles.
Viable C. immitis
was isolated from four of the six soil samples using a modified yeast extract medium.
After discharge, a bronchoalveolar lavage (BAL) culture was read as positive for C. immitis
She described two cases of chronic meningitis that illustrate different manifestations of C. immitis
. The first patient, a 16-year-old African American boy, had a history of exposure to soil in endemic areas, the likely source of his fungal infection, said Dr.
The infectious organism C. immitis
can be seen in the giant cells or extracellularly.
The geographic distribution of C. immitis
was thought to be restricted to central and southern California (7).
* Because of the clinical presentations, reported exposure to dirt, and published literature on EN outbreaks, the physicians and investigators hypothesized initially that this EN outbreak was caused by a mycotic agent (e.g., C. immitis
Ophuls and Moffitt proved that C. immitis
was a fungus rather than a protozoan in 1900.
Infection with C. immitis
previously has not been diagnosed in patients outside these areas, except in travelers returning from areas where the disease is endemic (1).
We describe the use of WGST to genotypically link C. immitis
isolates recovered from a transplant-related cluster of coccidioidomycosis in an area to which it is endemic.
The disease is acquired by inhaling the arthroconidia of C. immitis
present in the soil.