NPPC

(redirected from C-type natriuretic peptide)
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NPPC

A gene on chromosome 2q24-qter that encodes a member of the natriuretic peptide family. The secreted NPPB protein product binds to NPR2 and NPR3 receptors; it is involved in natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and plays a key role in cardiovascular homeostasis. NPPC also plays a role in endochondral ossification by regulating cartilaginous growth plate chondrocyte proliferation and differentiation.
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The sites of gene expression of atrial brain, and C-type natriuretic peptide in mouse foetal development: temporal changes in embryos and placenta.
Regulation of endothelial production of C-type natriuretic peptide by interaction between endothelial cells and macrophages.
Local expression of C-type natriuretic peptide suppresses inflammation, eliminates shear stress-induced thrombosis, and prevents neointima formation through enhanced nitric oxide production in rabbit injured carotid arteries.
C-type natriuretic peptide (CNP): a new member of natriuretic peptide family identified in porcine brain.
C-type natriuretic peptide and guanylyl cyclase B receptor.
Cardiomyocyte-restricted over-expression of C-type natriuretic peptide prevents cardiac hypertrophy induced by myocardial infarction in mice.
Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP).
Dwarfism and early death in mice lacking C-type natriuretic peptide.
C-type natriuretic peptide levels in cor pulmonale and in congestive heart failure.
N-Terminal pro-C-type natriuretic peptide, but not C-type natriuretic peptide, is greatly elevated in the fetal circulation.
Along with A- and C-type natriuretic peptides, BNP participates in the maintenance of cardiorenal function by increasing sodium excretion and reducing cardiac load and blood pressure (3, 4).
Physiologic and pathologic states leading to volume expansion and/or increased tension on cardiac myocytes lead to up-regulation of signals for the production and secretion of cardiac natriuretic prohormones, including A-, B-, and C-type natriuretic peptides (1).