NPPC

(redirected from C-type natriuretic peptide)
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NPPC

A gene on chromosome 2q24-qter that encodes a member of the natriuretic peptide family. The secreted NPPB protein product binds to NPR2 and NPR3 receptors; it is involved in natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and plays a key role in cardiovascular homeostasis. NPPC also plays a role in endochondral ossification by regulating cartilaginous growth plate chondrocyte proliferation and differentiation.
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Endothelium-derived C-type natriuretic peptide contributes to blood pressure regulation by maintaining endothelial integrity.
C-type natriuretic peptide regulation of limb mesenchymal chondrogenesis is accompanied by altered N-cadherin and collagen type X-related functions.
C-type natriuretic peptide (CNP) [5] is a paracrine growth factor (1) widely expressed in tissues including the vascular endothelium (2).
The SEHPLC column was calibrated by use of dextran blue (Vo), cytochrome C (~Mr 12 400), aprotinin (~Mr 6500), C-type natriuretic peptide (CNP) (~Mr 2000), angiotensin II (~Mr 1000), and glycine (Vt).
Natriuretic peptides are a family of structurally related hormones encoded by genes for atrial natriuretic peptide (ANP),* B-type natriuretic peptide (BNP), and C-type natriuretic peptide (CNP).
[2] This discovery was followed by identification of 2 structurally related pep tides in porcine brain, i.e., brain natriuretic peptide and C-type natriuretic peptide (CNP) (4, 5).
C-type natriuretic peptide (CNP) also possesses cardioprotective properties (3) but activates the homologous GC-B receptor (4).
C-type natriuretic peptide: the endothelial component of the natriuretic peptide system.
C-type natriuretic peptide levels in cor pulmonale and in congestive heart failure.
A single-nucleotide polymorphism in C-type natriuretic peptide gene may be associated with hypertension.
Chapter 3 does an excellent job of presenting the complete physiology, pathophysiology, biochemistry, and molecular biology of the natriuretic peptide family, including the noncardiac family members C-type natriuretic peptide and urodilatin.
Along with A- and C-type natriuretic peptides, BNP participates in the maintenance of cardiorenal function by increasing sodium excretion and reducing cardiac load and blood pressure (3, 4).