CLEC1B

(redirected from C-type lectin-like receptor-2)

CLEC1B

A gene on chromosome 12p13.2 that encodes a C-type lectin domain protein which acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding triggers tyrosine phosphorylation, spleen tyrosine kinase (Syk) binding, downstream tyrosine phosphorylation and activation of PLC-gamma-2. CLEC1B acts as an attachment factor for HIV-1, facilitating its capture by platelets. It is expressed in the liver, myeloid cells and on platelets.
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C-type lectin-like receptor-2 (CLEC-2) is a transmembrane platelet receptor for podoplanin and rhodocytin which have the ability to cause platelet aggregation.17Podoplaninis present on tumor cells, lymphatic and endothelial cells.