CLEC4D

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CLEC4D

A gene on chromosome 12p13.31 that encodes a C-type lectin domain protein which acts as an endocytic receptor. It is thought to be involved in antigen uptake at the site of infection, either clearing the antigen, or processing it and presenting it to T cells.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
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The next day, C-type lectin receptor agonists were added to the wells to a final concentration of 20 [micro]g/mL, 4 [micro]g/mL, and 1 [micro]g/mL.
The ADC is directed against a type I transmembrane glycoprotein and a C-type lectin receptor Ly75/ CD205, that is over-expressed in several solid tumors and non-Hodgking lymphomas (NHL).
L-SIGN or DC-SIGNR (also known as CD299, CD209L, and Clec4M) is a type-II transmembrane C-type lectin receptor homologous to DC-SIGN (77% amino acid sequence homology), highly expressed on liver sinusoidal cells, endothelial vascular cells, and in the lymph nodes, but not on DCs, in contrast to DC-SIGN (Table 1 and Figure 1).
Abbreviations AIM2: Absent in melanoma 2 BMDM: Bone marrow-derived macrophages CDN(s): Cyclic dinucleotide cGAMP: Cyclic GMP-AMP cGAS: Cyclic GMP-AMP synthase CLR(s): C-type lectin receptor GBP(s): Guanylate binding protein IFN: Interferon IFNAR: Type I IFN receptor MDP: Muramyl dipeptide NLR(s): NOD-like receptor PAMPs: Pathogen-associated molecular patterns PRRs: Pattern recognition receptors RIP: Receptor interacting protein/receptor interacting protein kinase RLR(s): RIG-I-like receptor SesT: Salmonella enterica serovar Typhimurium STING: Stimulator of interferon genes TLR(s): Toll-like receptor.
Another receptor frequently used for antigen targeting is the "mannose receptor" (MR/CD206), a C-type lectin receptor (CLR) not expressed on monocytes but highly expressed on DCs.
The C-type lectin receptor SIGNR3 binds to fungi present in commensal microbiota and influences immune regulation in experimental colitis.
Toll-like receptors (TLRs) can activate DCs by recognition of lipids, lipopolysaccharide, nucleic acid, etc.; whereas C-type lectin receptors (CLRs) can recognize the mannose-specific ligand on pathogen surface or glycoprotein of autoantigens.[7],[9] TLRs and CLRs synergistically activate DCs to produce various pro-inflammatory, anti-inflammatory cytokines and reactive oxygen species.[10]
Most classes of the human pathogens are recognized by c-type lectin receptors (CLR), which is one kind of PRR [4].
C-type lectin receptors (CLRs) present in cells of the immune system are glycan-binding receptors recognizing glycan structures in proteins and lipids.
C-type lectin receptors are a family of pattern-recognition receptors that recognize the structures of cell-surface polysaccharides.

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