The next day, C-type lectin receptor
agonists were added to the wells to a final concentration of 20 [micro]g/mL, 4 [micro]g/mL, and 1 [micro]g/mL.
The ADC is directed against a type I transmembrane glycoprotein and a C-type lectin receptor
Ly75/ CD205, that is over-expressed in several solid tumors and non-Hodgking lymphomas (NHL).
L-SIGN or DC-SIGNR (also known as CD299, CD209L, and Clec4M) is a type-II transmembrane C-type lectin receptor
homologous to DC-SIGN (77% amino acid sequence homology), highly expressed on liver sinusoidal cells, endothelial vascular cells, and in the lymph nodes, but not on DCs, in contrast to DC-SIGN (Table 1 and Figure 1).
Abbreviations AIM2: Absent in melanoma 2 BMDM: Bone marrow-derived macrophages CDN(s): Cyclic dinucleotide cGAMP: Cyclic GMP-AMP cGAS: Cyclic GMP-AMP synthase CLR(s): C-type lectin receptor
GBP(s): Guanylate binding protein IFN: Interferon IFNAR: Type I IFN receptor MDP: Muramyl dipeptide NLR(s): NOD-like receptor PAMPs: Pathogen-associated molecular patterns PRRs: Pattern recognition receptors RIP: Receptor interacting protein/receptor interacting protein kinase RLR(s): RIG-I-like receptor SesT: Salmonella enterica serovar Typhimurium STING: Stimulator of interferon genes TLR(s): Toll-like receptor.
Another receptor frequently used for antigen targeting is the "mannose receptor" (MR/CD206), a C-type lectin receptor
(CLR) not expressed on monocytes but highly expressed on DCs.
The C-type lectin receptor
SIGNR3 binds to fungi present in commensal microbiota and influences immune regulation in experimental colitis.
Toll-like receptors (TLRs) can activate DCs by recognition of lipids, lipopolysaccharide, nucleic acid, etc.; whereas C-type lectin receptors
(CLRs) can recognize the mannose-specific ligand on pathogen surface or glycoprotein of autoantigens., TLRs and CLRs synergistically activate DCs to produce various pro-inflammatory, anti-inflammatory cytokines and reactive oxygen species.
Most classes of the human pathogens are recognized by c-type lectin receptors
(CLR), which is one kind of PRR .
C-type lectin receptors
(CLRs) present in cells of the immune system are glycan-binding receptors recognizing glycan structures in proteins and lipids.
C-type lectin receptors
are a family of pattern-recognition receptors that recognize the structures of cell-surface polysaccharides.