CLEC4D

(redirected from C-type lectin receptor)

CLEC4D

A gene on chromosome 12p13.31 that encodes a C-type lectin domain protein which acts as an endocytic receptor. It is thought to be involved in antigen uptake at the site of infection, either clearing the antigen, or processing it and presenting it to T cells.
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Another receptor frequently used for antigen targeting is the "mannose receptor" (MR/CD206), a C-type lectin receptor (CLR) not expressed on monocytes but highly expressed on DCs.
Abbreviations APC: Antigen presenting cells CLR: C-type lectin receptor MFI: Mean fluorescence intensity MR: Mannose receptor moDC: Monocytes-derived dendritic cells RME: Receptor mediated endocytosis.
My approach to increase our understanding of fungal immune recognition is to (1) Characterize C-type lectin receptor complexes that drive innate recognition of C.
The C-type lectin receptor SIGNR3 binds to fungi present in commensal microbiota and influences immune regulation in experimental colitis.
PAMPs are recognized by host pathogen recognition receptors (PRRs), such as TLRs, nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs), retinoic acid-inducible gene-I-like receptors (RLRs), and C-type lectin receptors (CLRs).
Retinoic acid-inducible gene-I-like receptors and C-type lectin receptors Signaling Pathway
DNGR-1 (also known as CLEC9A) is a DC-restricted C-type lectin receptor (CLR) that recognizes the actin cytoskeleton exposed on necrotic cells.
C-type lectin receptors (CLRs) present in cells of the immune system are glycan-binding receptors recognizing glycan structures in proteins and lipids.
C-type lectin receptors are a family of pattern-recognition receptors that recognize the structures of cell-surface polysaccharides.

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