Objective: The C-terminal
domain (CTD) of the RNA polymerase II (RNAPII) largest subunit coordinates co-transcriptional processing and it is decorated by many processing factors throughout the transcription cycle.
The predicted RPG5 protein has a N-terminal nucleotide-binding site (NBS), leucine rich repeats (LRR) and C-terminal
protein kinase domain.
With funding by Amgen, Merck, Roche Diagnostics and Immunodiagnostic Systems, the Common/Consistent Normative Reference Population Database Study aims to define a common reference population database for a marker of bone formation (serum procollagen type I N propeptide, s-PINP) and a marker of bone resorption (serum C-terminal
telopeptide of type I collagen, s-CTX) C the two preferred bone turnover markers.
The ARR in the C-terminal
region comprises 6-8 ANK repeats (ANKs), which are necessary for binding to the Rel-homology domain of NF-[kappa]B and responsible for DNA binding, dimerization, and nuclear translocation (Huxford et al.
Baseline CTX (urinary C-terminal
crosslinking telopeptide) was the only bone turnover marker associated with subsequent bone loss, but this relationship was marginal.
Most of the fusion proteins can be expressed either with N- or C-terminal
These insights led the authors to propose a new "lock and trigger" model for spider silk formation, in which gradual pairing up of the N-terminal domains locks spidroins into a network of many protein molecules, while the changes of structure in the C-terminal
domains could trigger the rapid polymerization of spidroins into fibers.
The authors also found that while N-terminal domain tended to pair up with other molecules at the beginning of the duct and became increasingly stable as the acidity increased along the duct, the other end the C-terminal
domain destabilized as the acidity increased, and gradually unfolded until it formed the structure characteristic of silk at the acidic pH of 5.
The investigators also examined a molecular biomarker of cartilage tissue degradation: the urinary level of C-terminal
cross-linking telopeptide of type II collagen, which correlates with radiographic progression of OA.
6%; for the C-terminal
antiserum, BNP(19-29) <0.
Siva-1 consists of several distinct domains: an N-terminal region, a putative amphipathic helical (SAH) region, a death domain homology region (DDHR), and a C-terminal
cysteine-rich region that includes a B-BOX domain and a zinc-finger-like domain (2,3).
Serum kalsiyum, fosfor, magnezyum, 25-OH vitamin D, parathormon, alkali fosfataz ve kemik yapim (osteokalsin ve kemik-alkali fosfataz) ve yikim belirtecleri (N-terminal telopeptid kollajen tip 1-NTX ve C-terminal
telopeptid kollajen tip 1-CTX) olculdu.