C-terminal

C-terminal

 [ter´min-al]
the end of the peptide chain carrying the free alpha carboxyl group of the last amino acid, conventionally written to the right. See also n-terminal.

C-terminal

In chemical nomenclature, the alpha-carboxyl group of the last amino acid of a molecule.
References in periodicals archive ?
In particular, the processing and cleavage of C-terminal lysine from antibodies is one of the most commonly detected sources of product charge-heterogeneity.
(4,8) The majority of the AML patients have 2 CEBPA mutations with both N-terminal frameshift mutation and C-terminal inframe mutation on different alleles.
This lower MW was explained by the occurrence of more C-terminal cleavage of [PrP.sup.Sc] by protease K, as confirmed by the partial loss of the 12B2 epitope (Figure 2, panel B).
Sema3 proteins possess several furin-recognition motifs RXRR that are found at the Sema domain, plexinsemaphorins-integrin (PSI) domain, and C-terminal basic domain (9).
TUESDAY, July 31, 2018 (HealthDay News) -- A combined test of ubiquitin C-terminal hydrolase-L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) assay results has high sensitivity for detection of intracranial injury among patients with traumatic brain injury (TBI), according to a study published online July 24 in The Lancet Neurology.
De acuerdo con los resultados obtenidos por los investigadores, la deposicion de las proteinas beta-amiloides se acompana de una activacion del sistema inmune que lleva a la formacion en las microglias --las celulas que forman el mecanismo inmunitario en el sistema nervioso--de maculas de ASC (acronimo de Apoptosis-associated speck-like protein containing a C-terminal caspase-recruitment domain).
Yeast Mediator is required for diverse aspects of transcriptional regulation, such as activation, repression, stimulation of basal transcription, and TFIIH-dependent phosphorylation of the CTD (C-terminal repeat domain) of the Rpb1 subunit in vitro [2, 4].
Crystal structures of LpxA revealed that LpxA is composed of an unusual N-terminal left-handed parallel [beta]-helix domain and a C-terminal a-helical domain and forms a trimer with 3-fold symmetry (Figure 3) [25].
Protein 1 (NS1) in Influenza A H3N2 subtype virus binds to the fibrillarin via the C-terminal nuclear localization signal 2 (NLS2) [17].
In the initial work by O'Dowd et al., authors identified Cys341 in the receptor's C-terminal domain as a palmitoylation site and demonstrated a crucial role of [beta]2AR palmitoylation in the normal coupling of the receptor to the adenylyl cyclase (AC) signaling.
These antibodies were epitope mapped to the N-terminal (NFPRa) and C-terminal S/T-rich (NFPRb) regions of the carboxyl-terminal tail, respectively, [23].
We identified a novel homozygous missense mutation (c.5302G>C) in exon 31 of AGRN leading to the substitution of alanine to proline in the C-terminal LG2 domain of agrin (p.