In particular, the processing and cleavage of C-terminal
lysine from antibodies is one of the most commonly detected sources of product charge-heterogeneity.
(4,8) The majority of the AML patients have 2 CEBPA mutations with both N-terminal frameshift mutation and C-terminal
inframe mutation on different alleles.
This lower MW was explained by the occurrence of more C-terminal
cleavage of [PrP.sup.Sc] by protease K, as confirmed by the partial loss of the 12B2 epitope (Figure 2, panel B).
Sema3 proteins possess several furin-recognition motifs RXRR that are found at the Sema domain, plexinsemaphorins-integrin (PSI) domain, and C-terminal
basic domain (9).
TUESDAY, July 31, 2018 (HealthDay News) -- A combined test of ubiquitin C-terminal
hydrolase-L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) assay results has high sensitivity for detection of intracranial injury among patients with traumatic brain injury (TBI), according to a study published online July 24 in The Lancet Neurology.
De acuerdo con los resultados obtenidos por los investigadores, la deposicion de las proteinas beta-amiloides se acompana de una activacion del sistema inmune que lleva a la formacion en las microglias --las celulas que forman el mecanismo inmunitario en el sistema nervioso--de maculas de ASC (acronimo de Apoptosis-associated speck-like protein containing a C-terminal
Yeast Mediator is required for diverse aspects of transcriptional regulation, such as activation, repression, stimulation of basal transcription, and TFIIH-dependent phosphorylation of the CTD (C-terminal
repeat domain) of the Rpb1 subunit in vitro [2, 4].
Crystal structures of LpxA revealed that LpxA is composed of an unusual N-terminal left-handed parallel [beta]-helix domain and a C-terminal
a-helical domain and forms a trimer with 3-fold symmetry (Figure 3) .
Protein 1 (NS1) in Influenza A H3N2 subtype virus binds to the fibrillarin via the C-terminal
nuclear localization signal 2 (NLS2) .
In the initial work by O'Dowd et al., authors identified Cys341 in the receptor's C-terminal
domain as a palmitoylation site and demonstrated a crucial role of [beta]2AR palmitoylation in the normal coupling of the receptor to the adenylyl cyclase (AC) signaling.
These antibodies were epitope mapped to the N-terminal (NFPRa) and C-terminal
S/T-rich (NFPRb) regions of the carboxyl-terminal tail, respectively, .
We identified a novel homozygous missense mutation (c.5302G>C) in exon 31 of AGRN leading to the substitution of alanine to proline in the C-terminal
LG2 domain of agrin (p.