myc

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Myc

(mĭk)
n.
Any of several genes encoding DNA-binding proteins that can promote the development of various cancers when present at high concentrations.

myc

An oncogene on chromosome 8q24 of cellular (c-myc) or viral (v-myc) origin, which was first identified in the genome of a group of acutely transforming retroviruses capable of inducing avian neoplasia, possibly linked to RNA processing.

Physiological
c-myc is present in normal tissues; the protein product is required for progression through the cell cycle. Myc-null cell lines show profound growth defect, with lengthening of G1 and G2 phases of the cell cycle. There is a marked reduction in cyclin D1-CDK4 and D1-CDK6 complexes during entry to S phase, with lesser reductions in cyclin E2-CDK2 and cyclin A-CDK2. Myc induces expression of cyclins D1 and D2.

Pathological
Oncogenic expression of c-myc involves mutations on exon 2, which occur in more than 50% of Burkitt's lymphomas. The typical translocation in Burkitt’s lymphoma is t(8;14)(q24;q23), juxtaposing the c-myc and the immunoglobulin heavy-chain genes. Variant translocations are to 2p11 or 22q11, juxtaposing kappa or lambda light-chain genes respectively. FISH performed with dual probes can demonstrate the IgH/c-myc translocation. Tricolour with a probe against the centromere of chromosome 8 will control c-myc amplification or loss of the derivative chromosome 8; dual colour break-apart probes will show splitting of the gene.
References in periodicals archive ?
Although their findings have to be confirmed by further studies, Djouder believes that c-MYC inhibitors might be useful to mitigate radiation-induced gastrointestinal syndrome in patients.
These genes located on chromosome 8-such as c-MYC in 8q24, MOS in 8q22, ETO in 8q21.3-may play a significant role in the biology of myeloid lineage disorders via increased gene dosage leading to over-expression (14).
The two main things found were that TAF5L and TAF6L transcriptionally activate the oncogene c-Myc, and also regulate OCT4 that is the master regulator of the embryonic stem cells.
Polydatin (30 mM) treatment for 48 h significantly suppressed the mRNA and protein expression of beta-catenin, c-myc, cyclin D1, and survivin, and increased the mRNA and protein of DKK-1 in HepG2 cells (Figure 4A and B).
You want to remove all the abnormal tissue, and give it a chance to heal." Pathology supports the elevated presence of the c-Myc and beta catenin factors in the "healing incompetent" tissue around the edges of nonhealing wounds, he added.
Using OCI-AML3 cells we found that maximal suppression occurred within 30 mins of treatment with 0.5[micro]M JQ1 and the time frame was comparable to c-Myc downregulation (Figure 3(d)).
The previous report showed that activating Beclin-1-induced p62-mediated autophagic lysosomal degradation of c-Myc resulted in the inhibition of breast cancer cell proliferation [11].
Ashktorab et al., "The impact of C-MYC gene expression on gastric cancer cell," Molecular and Cellular Biochemistry, vol.
Subsequent studies demonstrated that EBV was a potent growth-transforming agent for primary B-cells, and that all cases of BLs carried characteristic chromosomal translocations resulting in constitutive activation of the c-MYC oncogene [6].
A key role in the regulation of protooncogenes, such as c-fos and c-myc, has also been attributed to HuR [21,66, 67].