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A gene on chromosome 1p32-p31 that is the putative transforming gene of avian sarcoma virus 17, which interacts directly with specific target DNA sequences to regulate gene expression.

Molecular pathology
JUN maps to a chromosome region involved in both translocations and deletions in cancer.


A family of oncogenes that can transform some normal cells (e.g., rat embryo cells) into cancer cells. All members of this family can bind to activating protein-1 (AP-1) sites and to specific DNA sequences. See: oncogene; transformation
References in periodicals archive ?
Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain.
The purpose of this study was to identify the potential role of the c-Jun N-terminal kinase (JNK) pathway in regulating these T cell responses in people diagnosed with MS.
IL8, TNF, C-JUN, and FOS were induced within 4 h ex vivo in both donors; by 24 h, there was nearly 100 times more ILS and C-JUN mRNA than the initial samples contained.
Though it normally help cells mature, c-jun can also act as a proto-oncogene, Timblin explains.
The study also reviews the importance of the relationships between WWOX and critical proto-oncogenes such as ErbB4 and c-Jun.
The active pharmaceutical ingredient, TRXE-002, has pan anti-cancer activity resulting in caspase-dependent apoptosis via c-Jun activation and pERK downregulation.
Moreover, activation of c-Jun N-terminal kinase (JNK) was detected after treatment with capillin preceding the appearance of characteristic properties of apoptosis.
Western blot analysis revealed gamma-T3 inhibited p38, extracellular signal-regulated kinase, and c-Jun N-terminal kinase/stress-activated protein kinase activation.
Our results show that p65 and c-Jun are two major components involved in NF[kappa]B and AP-1 activation, respectively.