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C-cell hyperplasia is divided into reactive or physiologic CCH and neoplastic CCH.
C-cell hyperplasia in multiple endocrine neoplasia 2A has demonstrated monoclonality, down-regulated apoptosis, and tumor-suppressor gene abnormalities consistent with intraepithelial neoplasia.
C-cell hyperplasia associated with chronic lymphocytic thyroiditis: a retrospective quantitative study of 112 cases.
Physiologic versus neoplastic C-cell hyperplasia of the thyroid: separation of distinct histologic and biologic entities.
This variability, particularly at low CT concentrations, led to the recommendation to use reliable and sensitive assays in the screening of MTC and C-cell hyperplasia (1).