CXCR4

(redirected from C-X-C chemokine receptor type 4)

CXCR4

A gene on chromosome 2q21 that encodes a seven-transmembrane G protein-coupled receptor belonging to the CXC chemokine receptor family, which binds specifically to stromal cell-derived factor-1, transducing a signal by increasing intracellular calcium ions and enhancing MAPK1/MAPK3 activation. It acts as a receptor for extracellular ubiquitin, is involved in haematopoiesis and in cardiac ventricular septum formation, plays a role in gastrointestinal tract vascularisation by regulating vascular branching and/or remodelling in endothelial cells, may be involved in cerebellar development and, in the CNS, may mediate hippocampal-neuron survival.

Molecular pathology
CXCR4 acts with the CD4 to support HIV entry into cells; it is highly expressed in breast cancer cells. CXCR4 mutations cause WHIM (warts, hypogammaglobulinaemia, infections, and myelokathexis) syndrome.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
On the basis of the observation that the chemokine stromal-derived factor 1 (SDF-1) is produced at high concentrations in classic metastatic sites in pancreatic cancer such as the liver, bone, and lung, we found that a subpopulation of [CD133.sup.+] cells that express the SDF-1 receptor CXCR4 (C-X-C chemokine receptor type 4) could be tracked in portal vein blood and that this cell subpopulation drove metastasis exclusively.
[3] Nonstandard abbreviations: CSC, cancer stem cell; SDF-1, stromal-derived factor 1; CXCR4, C-X-C chemokine receptor type 4.