Janknecht R, Cahill MA, Nordheim A (1995) Signal integration at the c-fos
Elevated expression of c-fos
in central nervous system correlates with visceral hypersensitivity in irritable bowel syndrome (IBS): a new target for IBS treatment.
Their results revealed that the expressions of COBRA1, c-Fos
, and c-Jun showed maximum levels in low-grade HCC cell line, i.
Therefore, this study we investigated the neuroanatomical functional site of the EL extracts (root) in rat spinal nucleus by means of c-Fos
Transduction pathways involved in the up-regulation of c-fos
All early genes, including c-fos
gene, can be activated by different harmful stimuli, such as cocaine, heroin, and other psychoactive drugs , "heat stress", adrenalectomy, intracortical injection of nerve growth factor (NGF), some medicines, and reduced diet.
Immunohistochemistry and Counting of c-Fos
Protein Immunoreactive Nuclei
Surprisingly, while measuring the expression of a protein called c-Fos
in the pleasure centre in the brain, the researchers found that Oreos triggered more neurons than cocaine or morphine.
14-16) In addition, many genes regulated by MAPKs are dependent on NF-[kappa]B, c-Fos
and c-Jun for transcription, thus activating the gene expressions of pro-inflammatory or antiviral cytokines to release IL-6, IFN-[beta] and TNF-[alpha].
Activation of the Gs[alpha]/ PKA/CREB pathway induces c-fos
over-expression in FD lesions [5-8].
As other psycho stimulants do, the acute administration of methylphenidate produces changes in gene regulation, increasing the expression of the transcription factor (immediate-early gene) c-fos
in a dose-dependent manner.
The researchers were able to quantify the physiologic response to exposure to acidic fumes by measuring a protein, c-Fos
, an indirect marker of nerve activity that is often expressed when nerve cells fire.