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A gene on chromosome 14q24.3 that encodes a leucine zipper DNA-binding FOS-type nuclear phosphoprotein, which dimerises with proteins of the JUN family to form the transcription factor complex AP1. FOS proteins regulate cell proliferation, differentiation and transformation, and may be associated with apoptosis.


A family of cancer-causing genes, first identified in viruses, that function within cells as transcription factors. Members of this family can transform normal cells (e.g., fibroblasts) into cancer cells (e.g., osteosarcomas, chondrosarcomas). See: oncogene; transformation


The name is derived from “FBJ osteosarcoma virus, ” in which these oncogenes were first identified.

References in periodicals archive ?
These sections were then incubated for 2- 3 days in primary antibody of oncogene rabbit c-Fos at the dilution of 1:3000 plus normal goat serum, Triton X-100 and.
Earlier patents covering oncology target protein kinase Akt, transcription factor Hif-1 and oncogene product c-fos, respectively.
Nc-5-s decreased LPS-induced phosphorylation of the extracellular regulated kinase (ERK) 1/2 and Akt kinase, but did not affect phosphorylation of the p38 kinase, activation of the nuclear factor kappa B pathway, nor DNA binding of c-fos.
AP1 comprises c-FOS and c-JUN, and these genes were assessed relative to glyceraldehyde 3-phosphate dehydrogenase (GAPDH) using qRT-PCR; primer sequences are shown in Supplemental Material, Table S2 (http://dx.
To gauge whether or not the naked mole-rats were responding physiologically to the acidic environment, the scientists measured a protein called c-Fos, which can help determine if nerve cells are firing.
Downstream targets of CD95 essential for cell growth, such as JNK, c-Fos and Egr1, also decreased their activity when the 'death receptor' was blocked.
Therefore, we studied the involvement of iron and ROS in the modulation of Jun N-terminal kinase 2 (JNK2) activity, c-jun and c-fos mRNA levels, key signaling steps in the transcriptional control of matrix-degrading metalloprotease (MMP)-1/interstitial collagenase and MMP-3/stromelysin-1 after UVB irradiation of human dermal fibroblasts in vitro.
Presentation Title: Effects of a topical alprostadil cream on expression of c-fos and oxytocin like immunoreactivity in hypothalamus of female rats.
In a second study, Repligen investigators injected secretin into mice and over the next 6 hours looked in the brain for signs of a protein called c-fos.
Patent 7,388,014 covers Rexahn's anticancer candidate, RX-0183 and related compounds, and are targeted, small molecule quinazoline analogues that inhibit key molecules such as c-Fos and Akt proteins.