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A gene on chromosome 14q24.3 that encodes a leucine zipper DNA-binding FOS-type nuclear phosphoprotein, which dimerises with proteins of the JUN family to form the transcription factor complex AP1. FOS proteins regulate cell proliferation, differentiation and transformation, and may be associated with apoptosis.
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A family of cancer-causing genes, first identified in viruses, that function within cells as transcription factors. Members of this family can transform normal cells (e.g., fibroblasts) into cancer cells (e.g., osteosarcomas, chondrosarcomas). See: oncogene; transformation


The name is derived from “FBJ osteosarcoma virus, ” in which these oncogenes were first identified.

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References in periodicals archive ?
In human injury response, c-Fos is paired with the gene c-Jun.
In contrast to c-Fos, Egr-1, and NPY-R, an ortholog for the immediate-early gene Arc has not been detected in zebrafish.
c-fos immunohistochemistry has been used to study neural activation patterns in a variety of brain regions following brief periods of enhanced sensory stimulation (e.g., [15-19]).
We performed quantitative RT-PCR and Western blotting to assess the expression of ATF2, IL-1[beta], IL-6, TNF, c-Fos, and c-Jun at the protein level.
(21.) Janknecht R, Cahill MA, Nordheim A (1995) Signal integration at the c-fos promoter.
Elevated expression of c-fos in central nervous system correlates with visceral hypersensitivity in irritable bowel syndrome (IBS): a new target for IBS treatment.
The c-fos serves as a marker of active neurons [90], and the expression of glial fibrillary acidic protein (GFAP) is a sign of active glial cells [76].
To investigate the effects of SMS on the osteoclastogenesis of HPDLSCs and PPDLSCs, the osteoclastogenesis-related genes RANKL and C-fos were examined by real-time RT-PCR.
For the estimation of c-Fos, NF-[kappa]Bp65, and histone, 12 [micro]g of protein from each nuclear fraction was electrophoresed through 10% sodium dodecylsulfate polyacrylamide gel (SDS-PAGE).
The role of JNK and p38 MAPK activities in UVA-induced signaling pathways leading to AP-1 activation and c-Fos expression.
In addition, according to the researchers, "AP-1 consists of both Fos and Jun genes' family members, which include c-Fos and c-Jun." The c-Fos protein has been previously found to briefly up-regulated in HCC's early stages and then quickly declines in the later stages of tumor progression - a process "for priming hepatocytes [predominant main cells of the liver] for migration and tissue invasion," Youssef and her team explained.