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A gene on chromosome 14q24.3 that encodes a leucine zipper DNA-binding FOS-type nuclear phosphoprotein, which dimerises with proteins of the JUN family to form the transcription factor complex AP1. FOS proteins regulate cell proliferation, differentiation and transformation, and may be associated with apoptosis.


A family of cancer-causing genes, first identified in viruses, that function within cells as transcription factors. Members of this family can transform normal cells (e.g., fibroblasts) into cancer cells (e.g., osteosarcomas, chondrosarcomas). See: oncogene; transformation


The name is derived from “FBJ osteosarcoma virus, ” in which these oncogenes were first identified.

References in periodicals archive ?
Janknecht R, Cahill MA, Nordheim A (1995) Signal integration at the c-fos promoter.
Elevated expression of c-fos in central nervous system correlates with visceral hypersensitivity in irritable bowel syndrome (IBS): a new target for IBS treatment.
Their results revealed that the expressions of COBRA1, c-Fos, and c-Jun showed maximum levels in low-grade HCC cell line, i.
Therefore, this study we investigated the neuroanatomical functional site of the EL extracts (root) in rat spinal nucleus by means of c-Fos immunohistochemistry.
All early genes, including c-fos gene, can be activated by different harmful stimuli, such as cocaine, heroin, and other psychoactive drugs [16], "heat stress", adrenalectomy, intracortical injection of nerve growth factor (NGF), some medicines, and reduced diet.
Immunohistochemistry and Counting of c-Fos Protein Immunoreactive Nuclei
Surprisingly, while measuring the expression of a protein called c-Fos in the pleasure centre in the brain, the researchers found that Oreos triggered more neurons than cocaine or morphine.
14-16) In addition, many genes regulated by MAPKs are dependent on NF-[kappa]B, c-Fos and c-Jun for transcription, thus activating the gene expressions of pro-inflammatory or antiviral cytokines to release IL-6, IFN-[beta] and TNF-[alpha].
Activation of the Gs[alpha]/ PKA/CREB pathway induces c-fos over-expression in FD lesions [5-8].
As other psycho stimulants do, the acute administration of methylphenidate produces changes in gene regulation, increasing the expression of the transcription factor (immediate-early gene) c-fos in a dose-dependent manner.
The researchers were able to quantify the physiologic response to exposure to acidic fumes by measuring a protein, c-Fos, an indirect marker of nerve activity that is often expressed when nerve cells fire.