Chlamydia trachomatis

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Chla·myd·i·a tra·cho·ma·tis

spheric nonmotile bacteria that are obligatory intracellular organisms; they form compact intracytoplasmic microcolonies up to 10 mcm in diameter that (by division) give rise to infectious spherules 0.3 mcm or larger in diameter, accumulate glycogen for a limited period in sufficient quantity to be detected by iodine stain, and are usually susceptible to sulfadiazine, tetracycline, and quinalones; various strains of this species cause trachoma, inclusion and neonatal conjunctivitis, lymphogranuloma venereum, mouse pneumonitis, nonspecific urethritis, epididymitis, cervicitis, salpingitis, proctitis, and pneumonia; chief agent of bacterial sexually transmitted diseases in the U.S.; the type species of the genus Chlamydia.

Chlamydia trachomatis

STD A human pathogen, similar to gonorrhea in transmission and disease; it is found in the cervix and urethra and survives in the throat or rectum Epidemiology It is the most common STD agent in the US–causing ± 4.5 million cases/yr; it is present in 1-3% of all ♂ and 15-40% of ♀ in STD clinics Clinical Inclusion conjunctivitis, lymphogranuloma venereum, urethritis, epididymitis and proctitis in ♂, mucopurulent cervicitis, endometritis, salpingitis–C trachomatis is implicated in 50% of salpingitis and PID, bartholinitis, and acute urethral syndrome in ♀ and conjunctivitis and pneumonia in neonates; infection may be asymptomatic Diagnosis Direct fluorescent antibody staining, solid phase immunoassay, ELISA, cell culture, nucleic acid probe, PCR Complications Fallopian tube destruction, ±infertility, ectopic/tubal pregnancy, preterm delivery, severe PID Management Doxycycline, azithromycin. Cf Mycoplasma pneumoniae.

Chla·myd·i·a tra·cho·ma·tis

(klă-mi'dē-a trak-ō'mă-tis)
Spheric nonmotile organisms that accumulate glycogen and are susceptible to sulfadiazine and tetracycline; various strains of this species cause trachoma, inclusion and neonatal conjunctivitis, lymphogranuloma venereum, nonspecific urethritis, epididymitis, cervicitis, salpingitis, proctitis, and pneumonia; chief agent of bacterial sexually transmitted diseases in the U.S. The type species of the genus Chlamydia.

Chlamydia trachomatis

A species that causes a great variety of diseases, including genital infections in men and women. The diseases caused by C. trachomatis include conjunctivitis, epididymitis, lymphogranuloma venereum, pelvic inflammatory disease, pneumonia, trachoma, tubal scarring, and infertility.

C. trachomatis is a commonly sexually transmitted pathogen (causing more than a million chlamydial infections in the U.S. each year). Men with chlamydial infection experience penile discharge and discomfort while urinating. Women may be asymptomatic or may experience urethral or vaginal discharge, painful or frequent urination, lower abdominal pain, or acute pelvic inflammatory disease, which may result in infertility.

Transmission of the disease can be prevented by avoiding contact with infected people and by using condoms during intimate sex. A pregnant woman with a chlamydial infection can transmit the disease to her newborn during birth. In newborns, ophthalmic antibiotic solution should be instilled in the conjunctival sac of each eye to prevent neonatal conjunctivitis and blindness caused by Chlamydia.


Several tests are available, including cultures, antigen detection assays, ligase chain reactions, polymerase chain reactions, and enzyme-linked immunoassays.


Erythromycin, azithromycin, or tetracycline is effective.


Tetracyclines are generally not recommended for pregnant women or children under 8 years old.
See also: Chlamydia
References in periodicals archive ?
In the 78 couples that included female partners who tested positive for C trachomatis by PCR, 53 male sexual partners (68%) also tested positive by PCR.
study suggests that compared to culture, PCR may be a more sensitive test for detecting C trachomatis in both males and females, and that contrary to previous studies which used culture, there is no significant difference between the efficiency of female-to-male and male-to-female transmission.
The prevalence of C trachomatis in this rural obstetric population emphasizes the importance of laboratory screening of rural pregnant women for this disease.
12] The prevalence of C trachomatis in pregnant patients ranges from 2% to 31%,[3,4] but most studies limit the range to between 8% and 12%.
0% of the women who reported a history of prior chlamydial infection were confirmed to have C trachomatis cervicitis at the time of the present study , whereas 10.
2% of women confirmed to be infected with C trachomatis had more than 10 leukocytes per high power field by vaginal wet-mount preparation examination (P = .
of concern about exposure to a sexually transmitted disease, only one had a culture positive for C trachomatis.
Inclusion criteria were that the subject be male, 18 years of age or older, and have symptoms of dysuria, a urethral discharge, or a history of sexual contact with a person infected with anogenital Neisseria gonorrhoeae or C trachomatis.
The purpose of the investigation reported here was a comparative evaluation of these two enzyme immunoassay test kits for the detection of C trachomatis endocervical infections.
To determine the prevalence of C trachomatis infection and clinical findings associated with infection in prenatal patients in a specific Native American population, all prenatal patients for a 6-month period were screened at their first prenatal visit.
A Gram stain examination of an endocervical swab sample has been used to predict mucopurulent cervicitis and C trachomatis but is thought not to be diagnostic.
C trachomatis seems to be a specific pathogen for humans,[29] and 15 serotypes have been recognized.