Cryptococcus neoformans

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Cryp·to·coc·cus ne·o·for·'mans

a species that causes cryptococcosis in humans and other mammals, particularly the cat family. Cells are spheric and reproduce by budding; a prominent feature is a polysaccharide capsule. Cryptococcus neoformans var. neoformans has a worldwide distribution and can often be isolated from weathered pigeon droppings. Cryptococcus neoformans var. gattii causes cryptococcosis in subtropical and tropical climates. This variety has been isolated from foliage and litter of species of eucalyptus.

Cryptococcus neoformans

a species of encapsulated yeasts that causes cryptococcosis, a potentially fatal infection that can affect the lungs, skin, and brain.

Cryp·to·coc·cus ne·o·for·mans

(krip-tō-kokŭs nē-ō-fōrmanz)
Fungal species that causes cryptococcosis in humans and other mammals, particularly the cat family. Some species isolated from foliage of species of eucalyptus trees.


a genus of yeastlike fungi.

Cryptococcus farciminosum
see histoplasmafarciminosum.
Cryptococcus neoformans
a species of worldwide distribution, causing cryptococcosis in all species including humans; there are two biovars, C. var neoformans, and C. var gattae. Called also Torula histolytica, Torulopsis neoformans.
References in periodicals archive ?
Phospholipase production by the egg yolk plate method, and in vitro susceptibility to fluconazole by using the disk diffusion test were performed on 17 C neoformans isolates.
The etiologic agent of cryptococcosis is the hasidiomycetous yeast Cryptococcus neoforrnans, (3,4) with 3 varieties recognized initially, C neoformans var grubii, (5) C neoformans var neoformans, and C neoformans var gattii.
Reports on bird species that harbor C neoformans in their droppings have been varied (7-12,21); however, avian cryptococcosis is considered rare in the avian patient, (22) probably because of the higher body temperature.
The spectrum of diseases caused by C neoformans ranges from pulmonary infection to disseminated disease frequently involving the central nervous system, and occasionally skin and bone.
Three days later, the patient's ascitic fluid culture grew C neoformans.
However, the gastrointestinal (GI) tract has been proposed as a potential site either following ingestion or possible direct inoculation of C neoformans into the blood stream following upper GI bleeding or overgrowth of fungus after antibiotic use.
2-4) The primary reservoir of C neoformans is birds; their droppings allow for transmission to humans via inhalation.
None of the other dimorphic fungi have the propensity for central nervous system involvement that C neoformans does.