In a high glucose environment, C elegans treated with rooibos extract exhibited an extended lifespan.
In this study, we investigated whether rooibos aqueous extract can protect C elegans against oxidative stress caused by the pro-oxidant juglone or a high glucose environment.
We found that aspalathin extended the life span of C elegans in a dose-depended manner under high glucose conditions.
According to the report, C elegans was the first multi-cellular organism to have its genetic structure completely mapped and many of its 20,000 genes perform the same functions as those in humans.
C elegans often feed on decaying fruit and vegetable matter.
Although neurodegeneration can easily be visualized in C elegans
by labeling neurons with fluorescent markers such as FITC (fluorescein isothiocyanate), DiI (l,l'-dioctadecyl-3,3,3',3',-tetramethylindo-carbocyanine perchlorate), DiO (3,3'-diocta-decyloxa carbocyanine perchlorate), and DiD (1,1'-dioctadecyl-3,3,3',3'-tetramethyl-indodicarbocyanine perchlorate) (Tong and Burglin 2010), the direct role of adiposity on neurodegeneration has not been explored to date.
When bathed in Prozac, C elegans
responds in two obvious ways.
Marc Vidal, whose laboratory at the Dana Farber Cancer Institute recently used the technology to create a complete gene collection for C elegans
, commented on the new architecture: "Our goal was to utilize this collection we created with Gateway(R) Technology across the spectrum of research involving C elegans
we can figure out what they're doing in C elegans and apply that to a whole myriad of human genetic issues," says Waterston.
What's missing from the C elegans genome may provide as much evolutionary insight as what's there.
Now, David Zarkower of the University of Minnesota Medical School in Minneapolis and his coworkers have identified a gene called mab-3 that governs aspects of male development for C elegans
, which is either male or hermaphroditic.
But in C elegans
at least, GABA sometimes excites nerve cells, McIntire and his coauthors report in the July 22 NATURE.