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The aim of this study was to evaluate the relationship between the presence of C difficile toxin A, thrombocytosis and leukocytosis.
All hospitalized patients with a positive fecal ELISA for C difficile toxin A between January 1, 2002 and July 28, 2003 were assessed for an elevated thrombocyte count (>400,000/[mm.
The correlation between leukocyte and thrombocyte count for patients with C difficile was determined using linear regression (SAS 8.
A total of 162 hospitalized patients were identified between January 1, 2002 and July 28, 2003 with a positive C difficile toxin A ELISA.
Our study suggests an association between C difficile infection and thrombocytosis.
Only patients, in whom attempts for detection of C difficile were made based on clinical suspicion, were assessed.
C difficile strains might lack the association with thrombocytosis.
Further studies will be necessary to determine whether thrombocytosis may be the only marker of C difficile infection in some patients and whether asymptomatic carriage is associated with thrombocytosis.