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Industrial solvent and purported health additive. Precursor in the synthesis of γ-hydroxybutyric acid.


n. Abbr. GBL
A chemical that has many industrial uses, especially as a solvent. It is a chemical precursor to gamma-hydroxybutyrate and is ingested illegally for its euphoriant and sedative effects.


(GBL) (gam'ă-byū'tir-ō-lak'tōn)
An industrial and household solvent that is readily metabolized after oral ingestion to gamma-hydroxybutyrate (GHB). Like GHB, it is marketed illicitly as a euphoriant, appetite suppressant, antidepressant, and sleep aid. It is more potent than GHB and has both a more rapid onset and a longer duration of action, but its pharmacologic and toxic properties are essentially the same: nausea, bradycardia, and central nervous system depression ranging from drowsiness and confusion to seizures, coma, and death. Dependency and severe withdrawal symptoms have been reported.
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References in periodicals archive ?
The substance - full name gamma butyrolactone is closely related to the banned gammahydroxybutrate (GHB) drug.
FDA Issues Alert about Misuse of Consumer Products Containing Gamma Hydroxybutyric Acid (GHB), Gamma Butyrolactone (GBL), and 1,4 Butanediol (BD) (June 15, 1999) (Letter (PDF), Poster) (see also January 21, 1999 Talk Paper)
For example, the FDA recently issued warnings about the use of gamma butyrolactone (GBL) and sought to pressure suppliers into voluntarily recalling the product.
Gamma butyrolactone (GBL) is an unapproved drug, not a supplement, says the FDA.
We have isolated eight compounds from TLFA, they were all identified as lignans with dibenzyl butyrolactone structure (Xu et al.
It is believed they had swallowed a chemical, possibly gamma butyrolactone - known more commonly as GBL.
Parthenogenetic activation and subsequent development of porcine oocytes activated by a combined electric pulse and butyrolactone I treatment.
Wright had denied intentionally administering a substance which the body transforms into Gamma Butyrolactone, knowing she did not consent, with the intention of stupefying or overpowering her to enable himself or another to engage in sexual activity with her.
Tests made later revealed Gamma Butyrolactone ( better known as GHB ( was in her bloodstream.
Over three years Calder transported thousands of litres of the chemical gamma butyrolactone (GBL) to co-accused Jamie Greiman in California.
The report estimates the market size of 1,4-butanediol industry for major applications such as tetrahydrofuran, polybutylene terphthalate, gamma butyrolactone, polyurethane, and others.
END-USE APPLICATIONS/INDUSTRY II-31 Applications of Succinic Acid Derivatives II-31 Chemicals II-32 Butanediol II-32 Gamma Butyrolactone II-32 Tetrahydrofuran II-32 Polybutylenesuccinate II-32 Pyrrolidones II-33 Food Products II-33 Pharmaceuticals II-33 End-Uses of Bio-Based Succinic Acid II-33 Applications of Bio-Succinic Acid II-34 End-Use Applications & Industries of Succinic Acid and Succinic Anhydride II-35 5.