gamma-butyrolactone

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γ-butyrolactone

Industrial solvent and purported health additive. Precursor in the synthesis of γ-hydroxybutyric acid.

gamma-butyrolactone

(găm′ə-byo͞o′tə-rə-lăk′tōn′)
n. Abbr. GBL
A chemical that has many industrial uses, especially as a solvent. It is a chemical precursor to gamma-hydroxybutyrate and is ingested illegally for its euphoriant and sedative effects.

gam·ma-bu·ty·ro·lac·tone

(GBL) (gam'ă-byū'tir-ō-lak'tōn)
An industrial and household solvent that is readily metabolized after oral ingestion to gamma-hydroxybutyrate (GHB). Like GHB, it is marketed illicitly as a euphoriant, appetite suppressant, antidepressant, and sleep aid. It is more potent than GHB and has both a more rapid onset and a longer duration of action, but its pharmacologic and toxic properties are essentially the same: nausea, bradycardia, and central nervous system depression ranging from drowsiness and confusion to seizures, coma, and death. Dependency and severe withdrawal symptoms have been reported.
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References in periodicals archive ?
Gamma hydroxybutyrate (GHB) and gamma butyrolactone (GBL) withdrawal: Five case studies.
It is rich in [alpha]-methylene butyrolactone. (2) The aqueous extract have activity against Gram-positive as well as Gram-negative bacteria.
While GHB itself has not been sold over the counter in the United States since 1992, products containing gamma butyrolactone (GBL), a chemical converted in the body to GHB, still can be found in a number of dietary supplements sold in health food stores and gyms.
Furanone dihydro, also referred to as GEL (gamma butyrolactone), was marketed as helping build muscle, reduce stress, and aid in sleep (National Nutritional Foods Association, 1999).
Ephedra or Ephedrine DHEA (dehydroepiandrosterone) Melatonin Dieter's Teas L-Tryptophan Folic Acid Gamma Hydroxybutyric Acid (GHB), Gamma Butyrolactone (GBL), and 1,4 Butanediol (BD)
One of the more worrisome analogues of GHB is a widely used chemical solvent, gamma butyrolactone (GBL).
Some products that contain gamma butyrolactone (GBL) -- like Renewtrient, Revivarant, Blue Nitro and Gamma G -- are touted as performance enhancers.
SOLVENT MIXTURES may contain small amounts of methylene chloride mixed with other solvents, or new nonflammable stripping agents such as n-methyl-2-pyrrolidone (NMP) and gamma butyrolactone. You still must wear gloves and goggles, and most require ventilation.
(5.) For example, the FDA recently issued warnings about the use of gamma butyrolactone (GBL) and sought to pressure suppliers into voluntarily recalling the product.
For example, FDA issued a January 1999 warning about illegally marketed and unapproved "dietary supplements" containing gamma butyrolactone (GBL).
* Gamma butyrolactone (GBL) is an unapproved drug, not a supplement, says the FDA.