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buspirone hydrochloride


Pharmacologic class: Azaspirodecanedione

Therapeutic class: Anxiolytic

Pregnancy risk category B


Unclear. Thought to bind to serotonin and dopamine receptors in CNS, increasing dopamine metabolism and impulse formation. Also thought to inhibit neuronal firing and reduce serotonin turnover.


Tablets: 5 mg, 7.5 mg, 10 mg, 15 mg, 30 mg

Indications and dosages

Anxiety disorders; anxiety symptoms

Adults: 7.5 mg P.O. b.i.d.; increase by 5 mg/day q 2 to 3 days as needed (not to exceed 60 mg/day). Common dosage is 20 to 30 mg/day in divided doses.

Off-label uses

• Parkinsonian syndrome

• Symptomatic relief of depression


• Hypersensitivity to drug

• Severe renal or hepatic impairment

• MAO inhibitor use within past 14 days


Use cautiously in:

• patients receiving concurrent anxi-olytics or psychotropics

• pregnant or breastfeeding patients

• children.


• Give with food to minimize GI upset.

• Know that full benefit of drug therapy may take up to 2 weeks.

Adverse reactions

CNS: dizziness, drowsiness, nervousness, headache, insomnia, weakness, personality changes, numbness, paresthesia, tremor, dream disturbances

CV: chest pain, palpitations, tachycardia, hypertension, hypotension

EENT: blurred vision, conjunctivitis, tinnitus, nasal congestion, sore throat

GI: nausea, vomiting, diarrhea, constipation, abdominal pain, dry mouth

GU: dysuria, urinary frequency or hesitancy, menstrual irregularities, menstrual spotting, libido changes

Musculoskeletal: myalgia

Respiratory: chest congestion, hyperventilation, dyspnea

Skin: rash, alopecia, blisters, pruritus, dry skin, easy bruising, edema, flushing, clammy skin, excessive sweating

Other: altered taste or smell, fever


Drug-drug. Erythromycin, itraconazole: increased buspirone blood level

MAO inhibitors: hypertension Trazodone: increased risk of adverse hepatic effects

Drug-food. Grapefruit juice: increased buspirone blood level and effects

Drug-herbs. Hops, kava, skullcap, valerian: increased CNS depression

Drug-behaviors. Alcohol use: increased CNS depression

Patient monitoring

• Monitor mental status closely.

• Assess hepatic and renal function regularly to detect drug toxicity.

Patient teaching

• Instruct patient to take drug with food.

• Advise patient not to use drug to manage everyday stress or tension.

• Instruct patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• Caution patient to avoid alcohol because it increases CNS depression.

• Emphasize importance of keeping follow-up appointments to check progress.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs, foods, herbs, and behaviors mentioned above.


A trademark for the drug buspirone hydrochloride.


a trademark for an oral antianxiety drug (busPIRone hydrochloride).


An anti-anxiolytic psychotropic agent of the azaspirodecanedione class, which is unrelated to benzodiazepines, barbiturates or other sedatives.
Adverse effects
Dizziness, insomnia, nervousness, drowsiness, lightheadedness, nausea, diarrhoea, headache, fatigue.

Avoid MAOIs when using buspirone.
Oral and transdermal; initial adult dosage is 15 mg/day; maximum, 60 mg/day.
Mechanism of action
Buspirone has an affinity for both serotonin (5-HT1A) and dopamine (D2) receptors; its mechanism of action is currently unknown.


Buspirone, see there.


A brand name for BUSPIRONE.
References in periodicals archive ?
Buspar (busipirone) is a non-benzodiazepines that has also been approved for the treatment of Generalized Anxiety Disorder (Fuller & Sajatovic, 2001).
The complaint alleges that Bristol submitted patents for listing in the Orange Book after an Abbreviated New Drug Application already had been filed with the FDA--and in the case of BuSpar, literally hours before generic rivals were set to enter the market.
The suit, filed by the consumer coalition Prescription Access Litigation (PAL) project, charged that the company illegally manipulated patent law to keep a generic, cheaper version of BuSpar off the market, at great cost to consumers.
Buspar About InteliHealth To provide the highest standards of quality, the information on the InteliHealth site is reviewed and approved by Johns Hopkins, the nation's best hospital for eight consecutive years according to U.
75 (Panic Attack: 2-6) Buspirone Buspar 30 Diphenhydramine(***) Benadryl 50 Hydroxyzine(***) Atarax/ 50 Vistaril Chloral Hydrate(***) 750 * Added by JW Cooper to correct omission in OBRA.
The sign revolved high above the convention center floor, towering over exhibits for other over-hyped psycho active drugs, such as Prozac and BuSpar.
The drug was approved in 1986 under the name BuSpar for the management of anxiety disorders or the short-term relief of the symptoms of anxiety.
BuSpar Buspirone, introduced under the brand name BuSpar in 1986, is manufactured by Bristol-Myers Squibb as a medication to treat patients suffering from generalized anxiety disorder.
used illegal tactics to maintain a monopoly on the manufacture, distribution, and sales of its antianxiety drug BuSpar (buspirone).