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an anticholinergic and antimuscarinic alkaloid derived from various plants, having a depressant effect on the central nervous system. Used as an antisialagogue preanesthetic medication and as an adjunct to general anesthesia, administered parenterally; as an antiemetic, administered orally or parenterally; and as a cycloplegic and mydriatic, applied topically to the conjunctiva. Called also hyoscine.

scopolamine (hyoscine (UK))

Scopoderm TTS (UK), Transderm-Scop, Transderm-V (CA)

scopolamine hydrobromide (hyoscine hydrobromide)

Buscopan (UK), Kwells (UK)

Pharmacologic class: Antimuscarinic, belladonna alkaloid

Therapeutic class: Antiemetic, antivertigo agent, anticholinergic

Pregnancy risk category C


Acts as competitive inhibitor at postganglionic muscarinic receptor sites of parasympathetic nervous system and on smooth muscles that respond to acetylcholine but lack cholinergic innervation. May block cholinergic transmission from vestibular nuclei to higher CNS centers and from reticular formation to vomiting center.


Injection: 1 mg/ml in 1-ml vials, 0.4 mg/ml in 0.5-ml ampules and 1-ml vials, 0.86 mg/ml in 0.5-ml ampules

Transdermal system (Transderm-Scop): 1.5 mg/patch (releases 0.5 mg scopolamine over 3 days)

Indications and dosages

Preanesthetic sedation and obstetric amnesia

Adults: 0.3 to 0.6 mg I.M., I.V., or subcutaneously 45 to 60 minutes before anesthesia, usually given with analgesics

Postoperative nausea and vomiting

Adults: One transdermal patch placed behind ear on evening before surgery and kept in place for 24 hours after surgery. For cesarean section, one transdermal patch placed behind ear 1 hour before surgery.

Motion sickness

Adults: One transdermal patch placed behind ear 4 hours before anticipated need, replaced q 3 days if needed


• Hypersensitivity to scopolamine, other belladonna alkaloids, or barbiturates

• Hypersensitivity to bromides (injection only)

• Angle-closure glaucoma

• Acute hemorrhage

• Myasthenia gravis

• Obstructive uropathy (including prostatic hypertrophy)

• Obstructive GI disease (including paralytic ileus and intestinal atony)

• Reflux esophagitis

• Ulcerative colitis or toxic megacolon

• Hepatic or renal impairment

• Chronic lung disease (with repeated doses)


Use cautiously in:

• suspected intestinal obstruction; pulmonary or cardiac disease; tachyarrhythmia or tachycardia; open-angle glaucoma; autonomic neuropathy; hypertension; hyperthyroidism; ileostomy or colostomy

• history of seizures or psychosis

• elderly patients

• pregnant or breastfeeding patients (safety not established)

• children.


• For I.V. use, give by direct injection at prescribed rate after diluting with sterile water.

• After removing protective strip from transdermal patch, avoid finger contact with exposed adhesive layer to prevent contamination.

Adverse reactions

CNS: drowsiness, dizziness, confusion, restlessness, fatigue

CV: tachycardia, palpitations, hypotension, transient heart rate changes

EENT: blurred vision, mydriasis, photophobia, conjunctivitis

GI: constipation, dry mouth

GU: urinary hesitancy or retention

Skin: decreased sweating, rash


Drug-drug. Antidepressants, antihistamines, disopyramide, quinidine: additive anticholinergic effects

Antidepressants, antihistamines, opioid analgesics, sedative-hypnotics: additive CNS depression

Oral drugs: altered absorption of these drugs

Wax-matrix potassium tablets: increased GI mucosal lesions

Drug-herbs. Angel's trumpet, jimsonweed, scopolia: increased anticholinergic effects

Drug-behaviors. Alcohol use: increased CNS depression

Patient monitoring

• Assess vital signs and neurologic, cardiovascular, and respiratory status.

• Monitor patient for urinary hesitancy or retention.

Patient teaching

• Tell patient transdermal patch is most effective if applied to dry skin behind ear 4 hours before traveling.

• Caution patient to avoid touching exposed adhesive layer of transdermal patch.

• Advise patient to wash and dry hands thoroughly before and after applying patch.

• If patch becomes dislodged, instruct patient to remove it and apply new patch on a different site behind ear.

• Tell patient that using patch for more than 72 hours may cause withdrawal symptoms (headache, nausea, vomiting, dizziness). Advise him to limit use when feasible.

• Inform patient that his eyes may be markedly sensitive to light during patch use. Instruct him to wear sunglasses and use other measures to guard eyes from light.

• Caution patient to avoid alcohol because it may increase CNS depression.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs, herbs, and behaviors mentioned above.


(skō-pol'ă-mēn, -min),
An alkaloid found in the leaves and seeds of Hyoscyamus niger, Duboisia myoproides, Scopolia japonica, S. carniolica, Atropa belladonna, and other solanaceous plants; exerts anticholinergic actions similar to that of atropine, but is thought to have greater central nervous system effects; useful in preventing motion sickness; available as various salts.
Synonym(s): hyoscine


/sco·pol·a·mine/ (sko-pol´ah-mēn) an anticholinergic alkaloid obtained from various solanaceous plants; used as the base or the hydrobromide salt as an antiemetic and as the hydrobromide salt as a preanesthetic antisialagogue, adjunct to general anesthesia, and topical mydriatic and cycloplegic.


(skə-pŏl′ə-mēn′, -mĭn)
An alkaloid drug, C17H21NO4, extracted from plants such as henbane and used primarily to treat motion sickness and nausea and to dilate the pupil. Also called hyoscine.


Etymology: Giovanni A. Scopoli, Italian naturalist, 1723-1788
an anticholinergic alkaloid obtained from the leaves and seeds of several solanaceous plants. It is a central nervous system depressant.
indications It is prescribed for prevention of motion sickness and as an antiemetic, a sedative in obstetrics, and a cycloplegic and mydriatic.
contraindications Narrow-angle glaucoma, asthma, myasthenia gravis, obstruction of the genitourinary or GI tract, severe ulcerative colitis, and known hypersensitivity prohibit its use.
adverse effects Among the more serious adverse effects are blurred vision, central nervous system effects, tachycardia, dry mouth, decreased sweating, and hypersensitivity reaction. Also called hyoscine. See also transdermal scopolamine.


®Therapeutics An atropine-like anticholinergic–or antimuscarinic, used in preanesthesia, where CNS depression is desirable, GI tract antispasmodic, to ↑ heart rate, and counteract vasodilation and low BP caused by choline esters Metabolism GI tract absorption,12 metabolized in liver, remainder in kidneys Adverse efects Dry mouth, tachycardia, palpitation, pupillary dilatation, blurring of vision, headache, dry
hot skin


An alkaloid found in the leaves and seeds of Hyoscyamus niger, and other solanaceous plants; exerts anticholinergic actions similar to that of atropine, but thought to have greater central nervous system effects; useful in preventing motion sickness; available as various salts.
Synonym(s): hyoscine.


An ATROPINE-like drug used in premedication as a sedative and to dry up respiratory and salivary secretions.


(skō-pol'ă-mēn, -min)
An alkaloid found in the leaves and seeds of various plants; exerts anticholinergic actions similar to that of atropine, but is thought to have greater central nervous system effects; useful in preventing motion sickness.
Synonym(s): hyoscine.


an anticholinergic alkaloid derived from various plants, used as the hydrobromide in parasympathetic blockade and as a central nervous system depressant.
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