Buruli ulcer


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Bu·ru·li ul·cer

an ulcer of the skin, with widespread necrosis of subcutaneous fat, due to infection with Mycobacterium ulcerans; occurs in Uganda in persons living on the Nile river banks.
[Buruli, district in Uganda]
A necrotizing skin ulcer caused by Mycobacterium ulcerans, first described in Uganda in 1897. It is characterised by slowly progressive, destructive skin and soft tissue infections
Prevention Cleaning of abrasions sustained outdoors, wearing protective clothing, and avoiding mosquito bites
Diagnosis Polymerase chain reaction testing of ulcer swabs or biopsies
Management Excision, which should include a small rim of healthy tissue; if small, excision may be adequate; more extensive disease may require antibiotics which may allow more conservative surgery

Bu·ru·li ul·cer

(bū-rū'lē ŭl'sĕr)
An infectiousdisease caused by Mycobacterium ulcerans characterized by painless swelling that later develops into an ulcerative lesion.
[Buruli, district in Uganda]

Buruli ulcer

A serious skin disease caused by Mycobacterium ulcerans . The condition is rare in the Western world but common in humid rural areas in the tropics. There is destruction of subcuticular tissue so that large ulcers with undermined edges form. The organism produces a potent toxin called mycolactone. Antibiotic treatment is effective. Many cases were found in the Buruli district near Lake Kyoga.
References in periodicals archive ?
Buruli ulcer. Review of a neglected skin mycobacterial disease.
[6] World Health Organization, Buruli ulcer: Number of New Cases of Buruli Ulcer Reported (Per Year), WHO, Geneva, Switzerland, 2011, http://apps.who.int/neglected_diseases/ntddata/buruli/buruli.html.
Comparison of features of leprosy and Buruli ulcer (BU) Leprosy Characteristic Geography In > 90 countries (especially Brazil, India, Indonesia, Nepal) Epidemiology 2nd most common human mycobacterial disease Reported 2013 > 200,000 cases on treatment > 200,000 new cases diagnosed Underreporting Yes Organism M.
Ake et al., "Buruli ulcer in Liberia, 2012," Emerging Infectious Diseases, vol.
We observed a total cicatrization of Buruli ulcer lesions (Figure 2) and stopped the antimycobacterial treatment.
[2] World Health Organization, "Buruli ulcer disease (Mycobacterium ulcerans infection) Fact Sheet Nu199," World Health Organization, 2007, http://www.who.int/mediacentre/fact-sheets/ fs199/en/.
Protective efficacy of a DNA vaccine encoding antigen 85A from Myocobacterium bovis BCG against buruli ulcer. Infect.
Earlier epidemiological reports showed that Buruli ulcer outbreaks often occur near such still waters in the tropics.
Two debilitating diseases, Buruli ulcer and Guinea worm, have received special attention under the fund.
Buruli ulcer is a bacterial infection which gets under the skin and spreads until it falls off, leaving sufferers with whole areas of their legs exposed, often needing amputation.
The team will bring 100 pieces of postcard-sized cultured skin to the Ghana capital of Accra, where they will treat Buruli ulcer patients, since there is no equipment to cultivate skin in the west African country.
ALM is evolving its mission with a program that is code-named "Leprosy Plus," by identifying new diseases related or similar to leprosy, such as the Buruli ulcer. This is the flesh-eating, bacteria-borne disease that has recently made world-wide headlines.