Burkitt's lymphoma

(redirected from Burkitt's tumour)

Burkitt's lymphoma

 [berk´its]
a form of undifferentiated lymphoma, usually found in central Africa but also reported from other areas, and manifested most often as a large bone-destroying lesion in the jaw or as an abdominal mass. The epstein-barr virus (EB virus), a herpesvirus, has been isolated from Burkitt's lymphoma cells in culture, and has been implicated as a causative agent. Called also African lymphoma and Burkitt's tumor.

Burkitt's lymphoma

A tumour of B lymphocytes occurring mainly in Central Africa and New Guinea and associated with the Epstein Barr virus, spread by insects. It affects mainly the lower and upper jaws of young children but can affect most parts of the body. Burkitt's lymphoma was one of the first human tumours to be shown to be caused in this way. The tumour commonly spreads to the abdomen where large secondary masses may form, affecting the bowel. Immunosuppressive chemotherapy with cyclophosphamide or METHOTREXATE is apparently curative in 80% of early cases and about 40% of those with advanced, widespread disease. (Dennis Parsons Burkitt, 1911–93, English medical researcher, bran apostle, and Fellow of the Royal Society).

Burkitt's lymphoma

a common cancer of African children, producing tumours of the jaw and facial bones and affecting the spleen and lymph nodes. It is caused by the Epstein-Barr virus.
References in periodicals archive ?
Haemoglobin genotypes, ABO blood groups, and Burkitt's tumour. J Med Genet 1966;3:177-179.
Burkitt's lymphoma (or Burkitt's tumour, or malignant lymphoma Burkitt's type) is a cancer of B lymphocytes, named after Denis Parsons Burkitt, a surgeon who first described the disease in 1956 while working in equatorial Africa.
Initial experiments revealed the chemical serotonin, which is naturally produced in the body, activated a suicide programme in cells with Burkitt's tumours. A low Prozac dosage was found to block serotonin entry into cancerous cells, protecting them from self-destruction.