Burkitt's lymphoma


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Burkitt's lymphoma

 [berk´its]
a form of undifferentiated lymphoma, usually found in central Africa but also reported from other areas, and manifested most often as a large bone-destroying lesion in the jaw or as an abdominal mass. The epstein-barr virus (EB virus), a herpesvirus, has been isolated from Burkitt's lymphoma cells in culture, and has been implicated as a causative agent. Called also African lymphoma and Burkitt's tumor.

Burkitt's lymphoma

A tumour of B lymphocytes occurring mainly in Central Africa and New Guinea and associated with the Epstein Barr virus, spread by insects. It affects mainly the lower and upper jaws of young children but can affect most parts of the body. Burkitt's lymphoma was one of the first human tumours to be shown to be caused in this way. The tumour commonly spreads to the abdomen where large secondary masses may form, affecting the bowel. Immunosuppressive chemotherapy with cyclophosphamide or METHOTREXATE is apparently curative in 80% of early cases and about 40% of those with advanced, widespread disease. (Dennis Parsons Burkitt, 1911–93, English medical researcher, bran apostle, and Fellow of the Royal Society).

Burkitt's lymphoma

a common cancer of African children, producing tumours of the jaw and facial bones and affecting the spleen and lymph nodes. It is caused by the Epstein-Barr virus.
References in periodicals archive ?
Hsiao, "Ileocecal Burkitt's lymphoma presenting as ileocolic intussusception with appendiceal invagination and acute appendicitis," Journal of the Formosan Medical Association, vol.
Burkitt's lymphoma being one of the most aggressive forms of B-cell NHL, with replication approaching 100% has three clinical forms; endemic, sporadic and immunodeficiency associated.
Burkitt's lymphoma (60%) and osteosarcoma (55%) were found to affect patients in the age group of 1-20 years.
Some authors [23, 24] stated that primary genitourinary lymphomas are uncommon, and, in particular, primary Burkitt's lymphoma (BL) of the bladder or genitourinary tissue is extremely rare [23, 37].
Unlike in adults, the pathological diagnosis .of renal lymphoma in pediatric cases is commonly Burkitt's lymphoma. In 6%-70% or pediatric patients it presents in the form of numerous bilateral renal masses, versus a single unilateral lesion or bilateral mass lesions in 10%-20%, and a retroperitoneal mass with diffuse renal enlargement in 5%-10% (2), (3), (4).
Endemic Burkitt's lymphoma classically presents with abdominal involvement, commonly bowel, nodal and secondary renal involvement.'11 Gastrointestinal involvement is the most common presentation, with infiltration of the wall of the ileocaecal region, appendix and ascending colon being most frequent.'11 Nodal involvement may result in a confluent mass encasing and displacing the abdominal vasculature, [1] as seen in our patient.
According to the 2008 world health organization (WHO) classification, this tumor best fit in the category B-cell lymphoma unclassifiable (BCLU) with features intermediate between diffuse large B-cell lymphoma and Burkitt's lymphoma.
With the spread of HIV infection, cases of Burkitt's lymphoma were soon to be reported in AIDS patients throughout the world, and in these patients the EBV genome was demonstrated in between 25 and 40% of the patients.
He was diagnosed with non-Hodgkin's Burkitt's lymphoma in February 2007.
The distribution of markers (described in Table 1) in DLBCLs, Burkitt's lymphoma and plasmablastic lymphoma are CD20: 84%, 100%, and 0; CD10: 55%, 100%, and 0; Bcl-6: 45%, 80%, and 0; MUM-1: 41%, 20%, and 88%.
Individually, these and other so-called "endemic NCDs," including Burkitt's lymphoma, sickle cell disease, and tropical diseases, are far less common than are those within the WHO's "four-by-four" definition.
In 2007, Joe Andruzzi was diagnosed with and later cured of Burkitt's lymphoma, and the next year he and his wife founded the Joe Andruzzi Foundation to raise money for pediatric brain cancer research and to give financial assistance to patients and their families.