Burkitt's lymphoma


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Burkitt's lymphoma

 [berk´its]
a form of undifferentiated lymphoma, usually found in central Africa but also reported from other areas, and manifested most often as a large bone-destroying lesion in the jaw or as an abdominal mass. The epstein-barr virus (EB virus), a herpesvirus, has been isolated from Burkitt's lymphoma cells in culture, and has been implicated as a causative agent. Called also African lymphoma and Burkitt's tumor.

Burkitt's lymphoma

[bur′kits]
Etymology: Denis P. Burkitt, English surgeon in Africa, b. 1911
a malignant neoplasm composed of undifferentiated lymphoreticular cells that form a large osteolytic lesion in the jaw or, in children, an abdominal mass. The tumor, which is seen chiefly in Central Africa, is characteristically a gray-white mass sometimes containing areas of hemorrhage and necrosis. Central nervous system involvement often occurs, and other organs may be affected. The Epstein-Barr virus (EBV), a herpesvirus, is associated with this lymphoma however, most non-African cases are EBV negative. Chemotherapy can often cure the disease. Also called African lymphoma, Burkitt's tumor.

Burkitt's lymphoma

A tumour of B lymphocytes occurring mainly in Central Africa and New Guinea and associated with the Epstein Barr virus, spread by insects. It affects mainly the lower and upper jaws of young children but can affect most parts of the body. Burkitt's lymphoma was one of the first human tumours to be shown to be caused in this way. The tumour commonly spreads to the abdomen where large secondary masses may form, affecting the bowel. Immunosuppressive chemotherapy with cyclophosphamide or METHOTREXATE is apparently curative in 80% of early cases and about 40% of those with advanced, widespread disease. (Dennis Parsons Burkitt, 1911–93, English medical researcher, bran apostle, and Fellow of the Royal Society).

Burkitt's lymphoma

a common cancer of African children, producing tumours of the jaw and facial bones and affecting the spleen and lymph nodes. It is caused by the Epstein-Barr virus.

Burkitt's lymphoma,

n.pr malignant undifferentiated lymphoma usually found in central African children, marked by an enlarged mandible or by a growth in the retroperitoneal area; has been linked to the Epstein-Barr virus.
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Burkitt's lymphoma.

Burkitt's lymphoma, Burkitt's tumor

a form of undifferentiated malignant lymphoma in humans and primates, especially marmosets and some gibbons. Usually found in central Africa, but also reported from other areas, and manifested most often as a large osteolytic lesion in the jaw or as an abdominal mass; called also African lymphoma.
The Epstein-Barr virus (EB virus), a gammaherpesvirus, has been isolated from Burkitt's lymphoma cells in culture, and has been implicated as a causative agent. The same virus causes the relatively benign, though debilitating, disease infectious mononucleosis (glandular fever) of humans.
References in periodicals archive ?
Gastric Burkitt's lymphoma is an aggressive tumor with high proliferation; we are yet to find the optimal treatment to this disease to help its poor prognosis.
This study found an almost equal frequency of Burkitt's lymphoma and osteosarcoma (10 and 9 cases respectively).
Imaging of Burkitt's lymphoma in pediatric patients.
A total of 44 patients (61%) were classified as DLBCL, 11 (15%) were Burkitt's lymphomas, 9 (13%) were plasmablastic lymphomas and 7 (10%) were high grade lymphomas.
Plasma cell infiltrates Florid plasma cell expansion in lymph nodes, tissues and bone marrow with polyclonal hypergammaglobulinemia HHV8-associated pathologies MCD MCD with so-called microlymphoma MCD with lymphoma MCD with Kaposi's sarcoma MCD with HHV8 associated haemophagocytic syndrome Lymphomas specifically occurring in HIV-positive patients Plasmablostic lymphoma Primary effusion lymphoma--classical and 'solid' forms Lymphomas orising in MCD Lymphomas occurring In other immunodeficient states Lesions similar to polymorphic post-transplant lymphoproliferative disorder Lymphomas also occurring In immune competent patients Classical Hodgkin's lymphoma Burkitt's lymphoma Diffuse large B-cell lymphoma MCD, multicentric Castleman's disease.
New studies in mice show that chloroquine may indeed prevent Burkitt's lymphoma and also a rare disease called ataxia telangiectasia that can lead to leukemia.
Primary pancreatic Burkitt's lymphoma mimicking carcinoma with obstructive jaundice and very high CA19-9.
Burkitt's lymphoma is the fastest-dividing lymphoma, with 100% of cells being in a cell cycle at any given time; it has been considered one of the most rapidly growing tumors in humans.
Cozzarelli, editor-in-chief of the Proceedings of the National Academy of Sciences and professor of molecular and cell biology at the University of California, Berkeley, died Sunday, March 19, at the age of 67, at his home in Berkeley, California, from complications related to treatment for Burkitt's lymphoma.
Golf: George Archer, winner of the 1969 Masters, has died at his home in Nevada after a long battle with Burkitt's Lymphoma.
Joshua has Burkitt's lymphoma, of which about 400 cases a year occur in the United States, his father said.
The data reported demonstrate that 1D09C3 selectively induces programmed cell death (apoptosis) in a variety of xenotransplant lymphoid tumor models, including non-Hodgkin's lymphoma, Hodgkin's lymphoma, multiple myeloma, and hairy cell leukemia, as well as new data in Burkitt's lymphoma.