The company believes that VNRX-5133, in a fixed combination with the fourth generation cephalosporin, cefepime, has the potential to provide a valuable broad-spectrum treatment option to meet unmet medical needs in patients with infections due to carbapenem-resistant pathogens including carbapenem-resistant Enterobacteriaceae and carbapenem-resistant Pseudomonas aeruginosa, suspected polymicrobial infections caused by both gram-negative and gram-positive susceptible pathogens, and engineerable bioterror pathogens such as Burkholderia
The bacteria in question come from the genera pseudomonas and burkholderia
. Once they enter the bloodstream, they are capable of causing serious, life-threatening infections, or temporary gastrointestinal distress without infection.
The lots, AR5407 and CD4565, do not meet Pfizer's "in-house microbiological specification for the potential presence of Genus Pseudomonas and Burkholderia
," the company said.
The bacteria found is Burkholderia
cepacia and a group of related strains.
In conjunction, DTRA will provide up to USD10m to fund the nonclinical biodefense aspects of the inter-agency collaboration, including execution of non-clinical potency and efficacy studies to test cefepime/VNRX-5133 against biothreat bacterial pathogens as well as Burkholderia
Ivacaftor use also correlated with reduced Staphylococcus aureus and Aspergillus species prevalence but was not associated with a reduction in Burkholderia
We will examine this hypothesis using the intracellular opportunistic pathogen Burkholderia
cenocepacia, which infects 2-10% of CF patients worldwide, rapidly accelerating their clinical decay.
T2MR Technology can detect five biothreat pathogens: New data show that the T2MR technology can detect five biothreat pathogens, including: Bacillus anthracis, Burkholderia
spp., Rickettsia prowazekii, Francisella tularensis and Yersinia pestis.
is a diverse genus of gram-negative bacteria, with isolates identified from a variety of environments, and ever more species being identified and classified.
 Among the seven cases studied in the present group, Burkholderia
pseudomallei was isolated from the bone marrow culture of one child.
mallei, draught horses, mallein test, real time PCR, PCA analysis.
Citrus aurantifolia Swingle fruits and leaves showed the strongest antibacterial activity against Haemopilus somnus and Burkholderia