Antiproliferative activity and new argininyl bufadienolide
esters from the "cururu" toad Rhinella (Bufo) schneideri.
Arenobufagin, a natural bufadienolide
from toad venom, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway.
Traditional Chinese Medicine has been widely used for anticancer treatment in China with a long history and many substances possess application prospect, such as bufadienolide
Arenobufagin, a bufadienolide
compound from toad venom, inhibits VEGF-mediated angiogenesis through suppression of VEGFR-2 signaling pathway.
compounds sensitize human breast cancer cells to TRAIL-induced apoptosis via inhibition of STAT3/Mcl-1 pathway," Apoptosis, vol.
Mckenzie RA, Franke FP, Dunster PJ (1987) The toxicity to cattle and bufadienolide
content of six Bryophyllum species.
(2009) found that newly laid Bufo marinus (Marine Toad) eggs contained high levels of bufadienolide
(toxin), whereas midstage tadpoles had lower levels and that all stages beyond the egg decreased in toxin diversity.
New insecticidal bufadienolide
, bryophyllin C, from Kalanchoe pinnata.
An endogenous bufadienolide
inhibitor of sodium pump, marinobufagenin, has also been shown to be increased in HF, and its plasma concentrations seem to correlate with severity of disease (65).
Hayashi, "New insecticidal bufadienolide
, bryophyllin C, from Kalanchoe pinnata," Bioscience, Biotechnology and Biochemistry, vol.
Jin et al., "A bufadienolide
derived androgen receptor antagonist with inhibitory activities against prostate cancer cells," Chemico-Biological Interactions, vol.
pinnatum leaf press juice (2.5-10%), a flavonoid fraction (0.1-1 mg/ml), and a bufadienolide
fraction (0.1-40 [micro]g/ml) on detrusor contractility was assessed and compared with controls (polar fraction (0.5-5 mg/ml) and oxybutynin ([10.sup.-8]-[10.sup.-6] M)).