Arenobufagin, a bufadienolide
compound from toad venom, inhibits VEGF-mediated angiogenesis through suppression of VEGFR-2 signaling pathway.
Mckenzie RA, Franke FP, Dunster PJ (1987) The toxicity to cattle and bufadienolide
content of six Bryophyllum species.
2009) found that newly laid Bufo marinus (Marine Toad) eggs contained high levels of bufadienolide
(toxin), whereas midstage tadpoles had lower levels and that all stages beyond the egg decreased in toxin diversity.
New insecticidal bufadienolide
, bryophyllin C, from Kalanchoe pinnata.
An endogenous bufadienolide
inhibitor of sodium pump, marinobufagenin, has also been shown to be increased in HF, and its plasma concentrations seem to correlate with severity of disease (65).
2% (1 mg/ml) while the bufadienolide
fraction had no inhibitory effect in the investigated concentrations.
is synthesized from cholesterol in the adrenal cortex by a pathway that is independent of cholesterol side-chain cleavage.
Preliminary data suggest that the bufadienolide
content in the chewable tablets used in the present study was less than 0.
Structure and stereochemistry of bryophyllin-A, a novel potent cytotoxic bufadienolide
orthoacetate from Bryophyllum pinnatum.
2001) reported that all bufadienolides
having an orthoacetate and alpha-pyrone moiety showed strong insecticidal activity.
Welzel, An Approach to Bufadienolides
from Deoxycholic Acid.
pinnata showed the presence of bufadienolides
, terpenoids and flavonoids (Costa et al.