bryostatin

(redirected from Bryostatins)

bryostatin

Any of a group of 20 different macrolide lactones isolated from a species of bryozoans (moss animals), a phylum of aquatic invertebrates (Bugula neritina), which upregulate protein kinase C (PKC) activity in the short term, and downregulate PKC with prolonged exposure. Bryostatin I inhibits cell growth and angiogenesis, drives cell differentiation and apoptosis and has immunomodulatory activity. While it showed promise as a memory enhancer and in cancer management, it failed as a monotherapy in phase-II clinical trials.
 
Adverse effects
Myalgia.
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(5.) AE Trinidad-Silva, GE Lim-Fong, KH Sharp and MG Haygood, "Bryostatins: Biological Context and Biotechnological Prospects," Current Opinion in Biotechnology, 21 (2010), 834-42.
Extracts of bryozoans were known to contain macrolides eventually named bryostatins (Pettit et al.
Identification of sibling species of the bryozoan Bugula neritina that produce different anticancer bryostatins and harbor distincts strains of the bacterial symbiont "Candidatus Endobuluga sertuld'.
Endobugula sertula" is reportedto be the source of the bioactive polyketide metabolites, the bryostatins (Davidson et al., 2001; Lopanik et al., 2004).
Bryostatins are a group of macrolide lactones first isolated in the 1960s by George Pettit from extracts of a species of bryozoan, Bugula neritina.
Spencer 3:00 STUDIES OF Fe(III) COMPLEXING WITH BRYOSTATINS, ANALOGS AND MARINE NATURAL PRODUCTS: MAKING BETTER PHAMECEUTICAL AGENTS, Jessica Thomas* and Thomas J.
The antitumor drugs include didemnins and dolastatins, obtained from ascidians (sea squirts), and bryostatins and halicondrins from bryozoa and sponges.
2004), whereas bryostatins, anticancer agents first isolated from the bryozoan Bugula neritina, require the microbial symbiont Endobugula sertula for their synthesis (Davidson et al.
The chemicals of focus are okadaic acid, brevetoxins, lyngbyatoxin A, caulerpenyne, bryostatins, and isocyano terpenes.
Marine Invertebrates: Bryostatins and Isocyano Terpenes
[C.sub.35] is examined by FT-ICR because its structure may represent the bryophan ring, the central structural feature in all bryostatins.