bryostatin

(redirected from Bryostatins)

bryostatin

Any of a group of 20 different macrolide lactones isolated from a species of bryozoans (moss animals), a phylum of aquatic invertebrates (Bugula neritina), which upregulate protein kinase C (PKC) activity in the short term, and downregulate PKC with prolonged exposure. Bryostatin I inhibits cell growth and angiogenesis, drives cell differentiation and apoptosis and has immunomodulatory activity. While it showed promise as a memory enhancer and in cancer management, it failed as a monotherapy in phase-II clinical trials.
 
Adverse effects
Myalgia.
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References in periodicals archive ?
Extracts of bryozoans were known to contain macrolides eventually named bryostatins (Pettit et al.
Pre-clinical studies have found that bryostatins can prevent ApoE4 from hindering BDNF production, and thus stop the chain reaction that may lead to Alzheimer's.
Identification of sibling species of the bryozoan Bugula neritina that produce different anticancer bryostatins and harbor distincts strains of the bacterial symbiont "Candidatus Endobuluga sertuld'.
Identification of sibiling species of the Bryozoan Bugula neritina that produce different anticancer bryostatins and harbour distinct strain of the bacterial symbiont "Candidatus Endobugula sertula".
Endobugula sertula" is reportedto be the source of the bioactive polyketide metabolites, the bryostatins (Davidson et al.
Spencer 3:00 STUDIES OF Fe(III) COMPLEXING WITH BRYOSTATINS, ANALOGS AND MARINE NATURAL PRODUCTS: MAKING BETTER PHAMECEUTICAL AGENTS, Jessica Thomas* and Thomas J.
The antitumor drugs include didemnins and dolastatins, obtained from ascidians (sea squirts), and bryostatins and halicondrins from bryozoa and sponges.
Eduardo MuSoz, lead inventor and Chief Scientific Officer of VivaCell Biotechnology EspaSa states that: "From our experiments using a specific and suitable model for HIV-1 reactivation, we determined which combinations of bryostatins and HDACs inhibitors synergise to antagonise HIV-1 latency.
2004), whereas bryostatins, anticancer agents first isolated from the bryozoan Bugula neritina, require the microbial symbiont Endobugula sertula for their synthesis (Davidson et al.
The chemicals of focus are okadaic acid, brevetoxins, lyngbyatoxin A, caulerpenyne, bryostatins, and isocyano terpenes.
This invention relates to pharmaceutical compositions, particularly pharmaceutical compositions comprising a bryostatin-1, other bryostatins and substituted derivatives of bryostatins for use in treating inflammation, and for use in combating arteriosclerosis, diseases of the cardiovascular system and the central nervous system, prior to and following organ transplantation, and ischemia [United States Patent Pending].