(5.) AE Trinidad-Silva, GE Lim-Fong, KH Sharp and MG Haygood, "Bryostatins
: Biological Context and Biotechnological Prospects," Current Opinion in Biotechnology, 21 (2010), 834-42.
Extracts of bryozoans were known to contain macrolides eventually named bryostatins
(Pettit et al.
Identification of sibling species of the bryozoan Bugula neritina that produce different anticancer bryostatins
and harbor distincts strains of the bacterial symbiont "Candidatus Endobuluga sertuld'.
Endobugula sertula" is reportedto be the source of the bioactive polyketide metabolites, the bryostatins
(Davidson et al., 2001; Lopanik et al., 2004).
are a group of macrolide lactones first isolated in the 1960s by George Pettit from extracts of a species of bryozoan, Bugula neritina.
Spencer 3:00 STUDIES OF Fe(III) COMPLEXING WITH BRYOSTATINS
, ANALOGS AND MARINE NATURAL PRODUCTS: MAKING BETTER PHAMECEUTICAL AGENTS, Jessica Thomas* and Thomas J.
The antitumor drugs include didemnins and dolastatins, obtained from ascidians (sea squirts), and bryostatins
and halicondrins from bryozoa and sponges.
2004), whereas bryostatins
, anticancer agents first isolated from the bryozoan Bugula neritina, require the microbial symbiont Endobugula sertula for their synthesis (Davidson et al.
The chemicals of focus are okadaic acid, brevetoxins, lyngbyatoxin A, caulerpenyne, bryostatins
, and isocyano terpenes.
Marine Invertebrates: Bryostatins
and Isocyano Terpenes
[C.sub.35] is examined by FT-ICR because its structure may represent the bryophan ring, the central structural feature in all bryostatins