AKAP13

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AKAP13

A gene on chromosome 15q24-q25 that encodes a member of the structurally diverse A-kinase anchor protein (AKAP) family, which binds to the regulatory subunits (RI/RII) of cAMP-dependent protein kinase A (PKA), confining PKA to discrete locations within the cell based on different targeting motifs. Alternative splicing of AKAP13 results in at least 3 transcript variants that encode different isoforms containing a dbl oncogene homology (DH) domain and a pleckstrin homology (PH) domain with various functions. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP-binding proteins, activating GTPase and resulting in signal transduction. The isoforms function as scaffolding proteins to co-ordinate a Rho-signalling pathway and function as PKA-anchoring proteins
References in periodicals archive ?
Arnold and Porter is acting as legal advisor to BRX in this transaction.
JO Hand, managing director of Jo Hand Recruitment, left, has been appointed to chair the Middlesbrough Business Referral Exchange Group (BRX).
BRX means before treatment and ARX means after 3-6 months of treatment while SE is standard error.
acidal black 10B--acidal navy blue 3BR--acid black 10A, 10B, 12B, 10BA, base M, 4BN, 4BNU, 10BN, BRX, BX, H, 1, or JVS--acid blue black B, 10B, BG, or double 600--acid leather blue IGW, dark blue G, or fast blue black G--airedale black 2BG--amacid black 10BR--atulacid black 10BX or BX--azanol fast acid black 10B--AZO dark blue C 2B, HR, S or SH--blue black 12B or SX--boruta black A--brasilan black BS--bucacid blue black--calcocid blue black--calcocid blue black 2R--C.I.
ALSO HIGHER: Brixmor (BRX) up 4.2% after being included in S&P 400 index.
Steadily Declining Leverage: Fitch expects BRX's leverage to sustain in the mid-6x range through 2020 as the company balances redevelopment expenditures, debt repayment and leverage-neutral share repurchase activity with proceeds from asset sales and retained cash flow.
(NYSE: BRX) operating results for the three months ended September 30, 2016 showed net income attributable to common stockholders was USD0.19 per diluted share compared with USD0.18 per diluted share in the comparable 2015 period.
Beauty Products, with mass distribution of a collection of such BB products as BB Super Gro Double Strength & Pump It Up Spritz; African Royale products such as Hot Six Oil & BRX Braid Spray; 4Naturals products such as Slick-It and Afro Stretch, and Tropical Roots products such as TR Growth Oil; Upscale magazine; Word of Faith Family Worship Cathedral; and The Ark of Salvation, a Christian outreach ministry.
6 issue of Real Estate Weekly, a bylined article "RE1T 1PO's making a big comeback, but is the timing right?" by Susan Persin of Trepp mentioned that Blackstone Group's Brixmor Property Group (BRX) filed for an IPO.
The car has been built in co-operation with Subaru, who have their own version - the Subaru BRX - and flat fours are a Subaru trademark.
Last year, in an article about Swarovski's new BRX and BRH reticle system, I asked the question whether "Glass with Class" costing upwards of $2,000 to $3,000 is worth the price over "Budget Minded Optics" costing only $300 to $500.