WASF3

(redirected from Brush-1)

WASF3

A gene on chromosome 13q12 that encodes a downstream effector involved in transmitting signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. WASF3 plays a role in regulating cell morphology and cytoskeletal organisation, and it is required in controlling cell shape.
References in periodicals archive ?
The BRUSH-1 gene, which Canji has obtained an option to license exclusively from the Geraldine Brush Cancer Research Institute at California Pacific Medical Center, will be a key part of Canji's pursuit of tumor suppressor therapies for breast cancer.
Helene Smith, a discoverer of the gene, commented: "It is very exciting for me, as a basic researcher, to work with Canji on BRUSH-1.
Canji management cautions that human trials of BRUSH-1 will depend on considerable research and could be several years away.