These cells may differentiate toward the surface, forming areas of gastric foveolar metaplasia or downwards giving rise to Brunner gland hyperplasia or Brunner gland hamartoma. According to this hypothesis, metaplastic foveolar epithelium originating from the "neo-G zone" is prone to mutation errors leading to the generation of dysplastic polyps, such as pyloric gland adenoma, and ultimately carcinoma.
C, Brunner gland hamartoma. At low power, it appears as a multilobular proliferation of Brunner glands (D) separated by a minor mesenchymal component of smooth muscle fibrous bands and adipose tissue (inset) (hematoxylin-eosin, original magnifications X10 [A], X20 [B, D, and D inset], and X4 [C]).
Nonneoplastic duodenal epithelial polyps include Brunner gland hyperplastic nodule/polyps (also known as Brunner gland hyperplasia), Brunner gland hamartomas, Brunner gland cysts, ectopic gastric mucosa, pancreatic heterotopia, hyperplastic polyps, inflammatory polyps, and hamartomatous polyps.
The distinction between Brunner gland hyperplastic nodules/polyps and Brunner gland hamartomas is arbitrary and has been traditionally based mainly on size.
Harty, "Evolution of brunner gland hamartoma associated with helicobacter pylori infection," Southern Medical Journal, vol.
Rutherford, "Gastrointestinal bleeding from brunner gland hamartoma," Clinical Gastroenterology and Hepatology, vol.
We report a case of Brunner gland hamartoma of the duodenal bulb with unusual histologic features.
Brunner gland hamartoma is a rare duodenal lesion, which was first described by Cruveilhier at the end of the 19th century.
Brunner gland hamartoma is a benign lesion, which can be treated by limited surgical resection or polypectomy.