Brown Tumour

Also found in: Encyclopedia.

A hyperparathyroidism-induced tumour-like mass of bony tissue characterised by fibrosis, cyst formation, marked osteoclastic resorption, multinucleated giant cells, and hemosiderin—which imparts the brown color deposits and rounded, cyst-like radiologic defects; brown tumours also occur in 2º hyperparathyroidism and may be the first sign of renal osteodystrophy in patients with ESRD who are kept alive by renal dialysis, and have enough time to develop the osseous reaction

References in periodicals archive ?

Gomez, "Peripheral brown tumour of hyperparathyroidism in the oral cavity," Oral Oncology Extra, vol.

Spontaneous and Excellent Healing of Bilateral Brown Tumors in Mandible after Endocrinal Therapy and Subtotal Parathyroidectomy: Case Report with 4-Year Follow-Up

Skeletal radiography revealed splaying of lower limb below the knee joint, decreased bone mineral density, thin cortices and several cystic brown tumours in pelvis and calvarium presenting the initiation of von Recklinghausen disease of bone (Figure-1).

Presentation of parathyroid adenoma with genu valgum and thoracic deformities

Brown tumours Mandible, clavicle, ribs, pelvis, long bones and hands 4.

Arm pain after syncope: diagnosis

Brown tumours are the end stage of primary or secondary hyperparathyroidism.

Based on these results, the osteolytic FDG avid bone lesions were classified as multiple brown tumours caused by primary hyperparathyroidism.

This case demonstrates that increased FDG uptake in clinically occult brown tumours can be misleading in the evaluation of a patient for malignancy.

Brown tumours of bone or osteoclastomata are highly vascular, lytic bone lesions representing a reparative cellular process rather than a neoplastic process usually seen in patients with hyperparathyroidism with hypercalcaemia.

Brown tumours exhibit no pathognomonic histological changes.

PET/CT-positive brown tumour--a potentially misleading finding in the evaluation of a patient for malignant primary tumour or metastases

Brown tumours show a high accumulation of FDG, probably as a result of the presence of giant cells.

Brown tumours represent a reparative cellular process rather than a neoplastic process that shows lytic lesions.