Such criteria were; alveolar generation, thickening in interalveolar septum, capillary hyperemia, hemorrhage, inflammatory cell infiltration, terminal bronchiole
structure, terminal bronchiole
debris, respiratory bronchiole
wall structure, respiratory wall debris, alveolar structure and edema in vascular wall.
Also, the injuries sustained by the study animals endured are not consistent with bronchiolitis obliterans in humans given that the animal injuries are mostly of the nasal and upper respiratory track rather than the alveoli or bronchioles
However, as fibrosis gets worse in either UIP/IPF or CHP with a UIP pattern, it tends to overrun the lobule, extending to encompass bronchioles
, so in advanced disease, it is sometimes impossible to separate those entities (Figure 2, C; and see Discussion).
In Group II was observed an increased amount of the number and caliber of the bronchi and bronchioles
(Figures 2D and 2E), decreased mesenchyme and the initial opening of the internal lumen of the bronchioles
Additionally, oral RGE treatment for 30 days prior to influenza virus infection significantly decreased the inflammation of the bronchioles
compared to non-exposure.
ResultsIn the control group, normal alveolar duct, alveolar spaces and terminal bronchioles
with regular size and shape of the alveoli were found (Figure-1).
However, compared to other avian influenza viruses, the attachment to epithelial cells by H7N9 in the bronchioles
and alveoli of the lung was more abundant and the viruses attached to a broader range of cell types.
Bacterial respiratory colonization and subsequent inflammation probably play an important role in dilating the bronchioles
and causing bronchiectasis--which leads to more colonization.
Alveoli were packed with serosanguineous mass and bronchioles
revealed degeneration in lining epithelial cells.
Bronchiolitis obliterans, or "popcorn lung," is a rare, irreversible, debilitating lung disease in which inflammation and scarring obstruct the smallest airways, the bronchioles
. There is no good treatment for the disease short of a lung transplant.
Although the disease was first described in 1835, long before microwave popcorn, most of the world had never before even heard of it.The irreversible condition, formally known as bronchiolitis obliterans, is an obstruction of the bronchioles
6 the smallest airways in the lungs.
A positive result by light microscopy was granular to diffuse red staining on the apical surface of epithelial cells in trachea, bronchi, and bronchioles
and on alveolar cells.