Rockford 1 Vinyl chloride 10 2 Vinyl chloride 10 1 cis-1,2-Dichloroethene 10 2 cis-1,2-Dichloroethene 10 Montana 1,2 Bromodichloromethane
120 1,2 Chloroform 120 Chamber 1-7 Trichloroethene 480 Exposure Experiment scenario Trial Avg.
Best et al., "Effects of bromodichloromethane
on ex vivo and in vitro luteal function and bromodichloromethane
tissue dosimetry in the pregnant F344 rat," Toxicology in Vitro, vol.
(2010)] and 0.3, 0.3, 0.8, and 1.8 [micro]g/L for chloroforom, bromodichloromethane
, dibromochloromethane, and bromoform, respectively, in residences consuming private well water.
The carrier gas was helium (5.7 psi) with an isothermal temperature of 45[degrees]C for bromoform, bromodichloromethane
, and dibromochloromethane and for chloroform a temperature program of 45[degrees]C for 2.6 minutes with a ramp of 20[degrees]C/ min.
Disposition of bromodichloromethane
in humans following oral and dermal exposure.
094K3725, purity [greater than or equal to] 99%) was obtained from Sigma, bromodichloromethane
However, the distribution among the four different THM species [chloroform (TCM), bromodichloromethane
(BDCM), dibromochloromethane (DBCM), and bromoform (TBM)] can vary appreciably, depending on the concentration of bromide in the water at the time chlorine is added for disinfection (Obolensky and Singer 2005).
Separate models for each area were conducted to predict chloroform, bromodichloromethane
, dibromochloromethane, broomcorn, and total THM and to assign a concentration to the distribution system of the municipality where women resided.
, dibromochloro-methane, and bromoform were measured using purge-and-trap gas chromatography/ mass spectrometry (GC/MS) (Tekmar 3100, Voyager MS; ThermoFisher, Waltham, MA, USA) following the method described by Lourencetti et al.
The change in the frequency of micronucleated lymphocytes after swimming increased in association with higher exhaled concentrations of the brominated THMs (p = 0.03 for bromodichloromethane
, p = 0.05 for chlorodibromomethane, p = 0.01 for bromoform) but not chloroform.
The four THMs--chloroform, bromodichloromethane
, dibromochloromethane, and bromoform--were measured in exhaled breath before swimmers entered the swimming pool (80 min before swimming) and just after they swam (5 min after leaving the pool) (Figure 1), as markers of individual exposure to DBPs.
In vitro biotransformation and genotoxicity of the drinking water disinfection byproduct bromodichloromethane
: DNA binding mediated by glutathione transferase theta 1-1.