broad-spectrum antibiotic

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antibiotic

 [an″te-, an″ti-bi-ot´ik]
1. destructive of life.
2. a chemical substance produced by a microorganism that has the capacity, in dilute solutions, to kill other microorganisms or inhibit their growth. Antibiotics that are sufficiently nontoxic to the host are used as chemotherapeutic agents in the treatment of infectious diseases. See also antimicrobial agent.
antineoplastic a's (antitumor a's) a class of antineoplastic agents that apparently affect the function or the synthesis, or both, of nucleic acids and thus are cell cycle nonspecific. See also antineoplastic therapy.
broad-spectrum antibiotic one that is effective against a wide range of bacteria, both gram-positive and gram-negative.
β-lactam antibiotic any of a group of antibiotics, including the cephalosporins and the penicillins, whose chemical structure contains a β-lactam ring.

broad-spec·trum an·ti·bi·ot·ic

an antibiotic having a wide range of activity against both gram-positive and gram-negative organisms.

broad-spectrum antibiotic

an antibiotic that is effective against a wide range of infectious microorganisms.

broad-spectrum antibiotic

A therapeutic array used to treat bacterial infections—e.g., acute otitis media.
 
Examples
Azithromycin, clarithromycin, cefixime, cefpodoxime proxetil, cefprozil, ceftriaxone, cefuroxime axetil, loracarbef.
 
Cons
Overuse of broad-spectrum antibiotics facilitates development of antibiotic-resistant infections and multi-drug resistance.

broad-spec·trum an·ti·bi·ot·ic

(brawd-spek'trŭm an'tē-bī-ot'ik)
An antibiotic having a wide range of activity against both gram-positive and gram-negative organisms.

antibiotic

1. destructive of life.
2. a chemical substance produced by a microorganism that has the capacity, in dilute solutions, to kill (biocidal activity) or inhibit the growth (biostatic activity) of other microorganisms. Antibiotics that are sufficiently nontoxic to the host are used as chemotherapeutic agents in the treatment of infectious diseases. See also antimicrobial.
3. used as feed additives to animals as growth promotants.

anthracycline a's
a group of antibiotics which have a tetracycline ring structure substituted with the sugar daunosamine. Includes the antineoplastic drugs doxorubicin and daunorubicin.
antineoplastic antibiotic
bactericidal antibiotic
one that kills bacteria.
bacteriostatic antibiotic
one that suppresses the growth of bacteria.
broad-spectrum antibiotic
one that is effective against a wide range of bacteria.
antibiotic detection
on-farm and prepackaged laboratory tests available for testing farm products and animal tissues and fluids for antibiotic residues.
antibiotic drugs
the range includes the following groups: penicillin, aminoglycoside, tetracycline, chloramphenicol, macrolide, nitrofuran, cephalosporins, and a miscellaneous group including bacitracin, tyrothricin, polymyxin, colistin.
antibiotic feed additives
see feed additives.
first generation antibiotic
one produced as a natural product, e.g. penicillin G. See second generation antibiotic (below).
antibiotic food preservation
is a satisfactory technique but very strictly controlled because of the problem of residues in the food. Used mostly for the preservation of fish.
antibiotic-induced diarrhea
see pseudomembranous colitis, acute undifferentiated diarrhea of the horse.
antibiotic residue in food
in human food of animal origin is a seriously regarded pollution in public health surveillance. The residues may arise from systemic administration, or even after absorption from a local site such as the uterus, but the most serious contamination arises from milk from quarters that have been treated for mastitis. It is essential for the safety of the human population, the financial well-being of the farmer and the professional reputation of the veterinarian that antibacterial withdrawal times are observed.
antibiotic resistance
see antimicrobial resistance.
second generation antibiotic
produced by manipulation of the molecular structure of a first generation antibiotic (see above) so that the metabolism and pharmacodynamics of the original compound are significantly altered.
antibiotic sensitivity test
see antimicrobial sensitivity test.
antibiotic therapy
antibiotics vary in their absorption from the alimentary tract, requiring some, e.g. streptomycin, to be given parenterally for systemic effect, freedom from toxicity, the range of bacteria against which they are effective, their capacity to stimulate resistance and whether they are bacteriostatic or bactericidal in their effects. Selection of the most suitable antibiotic to suit a particular circumstance may be guided by an antimicrobial sensitivity test, knowledge of the infection present and the price of the drug. In many instances, because of lack of knowledge of the infection present it is necessary to choose an agent with a broad antibacterial spectrum.
antibiotic withdrawal, antibiotic withholding
see antibacterial withdrawal time.
References in periodicals archive ?
In most cases this works because it targets every single species that could be the cause of the infection, but it just means you overuse broadspectrum antibiotics, which leads to resistance, and you expose patients to unnecessary drugs.
Despite prompt surgical debridement and the administration of broadspectrum antibiotics, septic shock and multiple organ dysfunction ensued.
In endemic areas, Lassa fever should be suspected in any patient who presents with fever and does not respond to antimalarials and broadspectrum antibiotics within a few days.
Broadspectrum antibiotics are routinely administered to women who have intra-amniotic infection, primarily to prevent the spread of infection beyond the uterus.
Culture identification of the pathogen should point to changing from broadspectrum antibiotics to more narrowspectrum regimens to avoid development of resistance.
In conclusion, the high frequency of multidrug resistant bacteria in ICUs suggests that we need to prescribe broadspectrum antibiotics more wisely in order to reduce pressure on sensitive strains.
It is possible that organisms will be implanted throughout the mucosal breach, and therefore broadspectrum antibiotics should be used prophylactically.
Despite the overall decline in antibiotic prescribing, it appears that "newer, more expensive broadspectrum antibiotics increasingly are being prescribed, even when there is little clear rationale for their use," Ms.
This article discusses the microbiology behind dog bites and highlights the need for proper wound hygiene and consideration of prophylactic broadspectrum antibiotics to prevent potentially fatal outcomes as a result of what initially seem to be minor injuries.
The increasing incidence of amoxicillin-resistant organisms, and the introduction of many newer broadspectrum antibiotics make choosing pharmacologic treatment for AOM more complex and challenging.
Because the signs of TTN are nonspecific and consistent with neonatal sepsis or pneumonia, most infants with TTN are evaluated for infection and are treated with broadspectrum antibiotics pen a definitive diagnosis.
The high incidence of SFI over the years is attributed to the widespread use of broadspectrum antibiotics, which reduce nonpathogenic bacterial populations that compete with fungi, and the growing number of persons with compromised immune systems caused by acquired immunodeficiency syndrome (AIDS), immunosuppressant drugs, and chemotherapy agents.