broad-spectrum antibiotic

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antibiotic

 [an″te-, an″ti-bi-ot´ik]
1. destructive of life.
2. a chemical substance produced by a microorganism that has the capacity, in dilute solutions, to kill other microorganisms or inhibit their growth. Antibiotics that are sufficiently nontoxic to the host are used as chemotherapeutic agents in the treatment of infectious diseases. See also antimicrobial agent.
antineoplastic a's (antitumor a's) a class of antineoplastic agents that apparently affect the function or the synthesis, or both, of nucleic acids and thus are cell cycle nonspecific. See also antineoplastic therapy.
broad-spectrum antibiotic one that is effective against a wide range of bacteria, both gram-positive and gram-negative.
β-lactam antibiotic any of a group of antibiotics, including the cephalosporins and the penicillins, whose chemical structure contains a β-lactam ring.

broad-spec·trum an·ti·bi·ot·ic

an antibiotic having a wide range of activity against both gram-positive and gram-negative organisms.

broad-spectrum antibiotic

A therapeutic array used to treat bacterial infections—e.g., acute otitis media.
 
Examples
Azithromycin, clarithromycin, cefixime, cefpodoxime proxetil, cefprozil, ceftriaxone, cefuroxime axetil, loracarbef.
 
Cons
Overuse of broad-spectrum antibiotics facilitates development of antibiotic-resistant infections and multi-drug resistance.

broad-spec·trum an·ti·bi·ot·ic

(brawd-spek'trŭm an'tē-bī-ot'ik)
An antibiotic having a wide range of activity against both gram-positive and gram-negative organisms.
References in periodicals archive ?
The extensive use of invasive devices, broadspectrum antibiotics and increased hospital stay are major factors contributing to the emergence of VRE.
"In most cases this works because it targets every single species that could be the cause of the infection, but it just means you overuse broadspectrum antibiotics, which leads to resistance, and you expose patients to unnecessary drugs.
Tarnow-Mordi, "Broadspectrum antibiotics for preterm, prelabour rupture of fetal membranes: the ORACLE I randomised trial," Lancet, vol.
Blood cultures were sent (grew pansensitive Streptococcus mutans and Enterococcus faecalis) and empiric broadspectrum antibiotics were started (piperacillin + tazobactam).
In our case, there was a history of recurrent Bartholin's gland abscess, and this might be due to the repeated exposures to the infections or improper use of strong broadspectrum antibiotics together with incision and drainage instead of management by marsupialization, as we know that incision and drainage have been shown to increase risk of Bartholin's gland abscess recurrences [12].
(2) UTI is often treated with different broadspectrum antibiotics when one with a narrow spectrum of activity may be appropriate because of concerns about infection with resistant organisms.
Similarly, children with metachromatic leukodystrophy are prone to healthcare- and device-associated infections involving opportunistic pathogens, and frequent use of broadspectrum antibiotics may predispose the children for infection with multidrug-resistant bacteria.
To control the symptoms of cystitis, the patient underwent multiple treatments with broadspectrum antibiotics during this 9-year period.
A survey on Incidence of broadspectrum antibiotics lactamase ESBL in Enterobacteriaceae isolated from patients hospitalized in Mofid Children Hospital in Tehran: Journal of ShahidBeheshti University of sciences.
The patient was firstly treated with broadspectrum antibiotics. However, after three days of no response to the antibiotic therapy, the patient was started on pulse methylprednisolone doses of one gram per day for five days along with pulse cyclophosphamide of 750 mg, and the antibiotics were also continued.
parapsilosis endocarditis present in this patient included in situ haemodialysis catheter, probable pre-existing chronic valve disease, admission broadspectrum antibiotics, and immunosuppression mediated by HIV and renal failure.
Mr Neal said: "The change, based on national guidance, reflected concerns that C.difficile rates were being driven by the widespread use of broadspectrum antibiotics such as ciprofloxacin."