broad-spectrum antibiotic


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antibiotic

 [an″te-, an″ti-bi-ot´ik]
1. destructive of life.
2. a chemical substance produced by a microorganism that has the capacity, in dilute solutions, to kill other microorganisms or inhibit their growth. Antibiotics that are sufficiently nontoxic to the host are used as chemotherapeutic agents in the treatment of infectious diseases. See also antimicrobial agent.
antineoplastic a's (antitumor a's) a class of antineoplastic agents that apparently affect the function or the synthesis, or both, of nucleic acids and thus are cell cycle nonspecific. See also antineoplastic therapy.
broad-spectrum antibiotic one that is effective against a wide range of bacteria, both gram-positive and gram-negative.
β-lactam antibiotic any of a group of antibiotics, including the cephalosporins and the penicillins, whose chemical structure contains a β-lactam ring.

broad-spec·trum an·ti·bi·ot·ic

an antibiotic having a wide range of activity against both gram-positive and gram-negative organisms.

broad-spectrum antibiotic

A therapeutic array used to treat bacterial infections—e.g., acute otitis media.
 
Examples
Azithromycin, clarithromycin, cefixime, cefpodoxime proxetil, cefprozil, ceftriaxone, cefuroxime axetil, loracarbef.
 
Cons
Overuse of broad-spectrum antibiotics facilitates development of antibiotic-resistant infections and multi-drug resistance.

broad-spec·trum an·ti·bi·ot·ic

(brawd-spek'trŭm an'tē-bī-ot'ik)
An antibiotic having a wide range of activity against both gram-positive and gram-negative organisms.
References in periodicals archive ?
In all of our analyses, we examine the use of narrow-spectrum antibiotics as well as broad-spectrum antibiotics, which have greater implications for the spread of antibiotic-resistant infections.
On multivariate analysis, the strongest independent predictors for prescribing broad-spectrum antibiotics for acute upper respiratory tract infections were physician specialty and geographic region.
Second, the injudicious use of broad-spectrum antibiotics may increase the potential for future development of antibiotic resistance.
SAN DIEGO -- Narrow-spectrum antibiotics yield outcomes that are at least comparable to, if not better than, broad-spectrum antibiotics when prescribed to children with appendicitis, according to a retrospective cohort study presented at the annual meeting of the Pediatric Academic Societies.
Given the likelihood that a woman whose infection has failed to respond to broad-spectrum antibiotics probably has an infected pelvic mass, it makes sense to routinely search for such a mass in nonresponders.
Motif Bio, a United Kingdom-based biopharmaceutical company, has received Qualified Infectious Diseases Product designation for its iclaprim, a broad-spectrum antibiotic, from the US FDA, it was reported yesterday.
Therefore, combination therapy "appears prudent" for patients at risk for multidrug resistance, such as children with a history of either colonization or infection with a resistant organism, children who have received broad-spectrum antibiotic therapy during the preceding month, children whose current hospitalization has been prolonged, and children residing in a community with a high prevalence of resistant pathogens.
Patients with an associated abscess or extensive cellulitis must be hospitalized and receive a broad-spectrum antibiotic.
"It is unclear whether use of the broad-spectrum antibiotic regimen would lower the postcesarean infection rate in a hospital that already has a very low rate of such infections," Dr.
This antibiotic destroys bacteria as effectively as ampicillin, a broad-spectrum antibiotic, Moore and her colleagues report in the Feb.
The lead compound in the EV-035 series is the broad-spectrum antibiotic GC-072, which is being developed with US government biodefense funding.
SAN FRANCISCO -- Black children were less likely than nonblack children to receive an otitis media diagnosis and, when treated for otitis media, were less likely to receive a broad-spectrum antibiotic, national survey data showed.