Further studies are needed to determine whether there may be specific subsets of patients for whom breast conservation therapy
may be a reasonable alternative to total mastectomy.
Generally, tumor size and location are not used as patient selection criteria for breast conservation therapy
except as they may influence the cosmetic outcome.
Similar survival with breast conservation therapy
or mastectomy in the management of young women with early-stage breast cancer.
In their paper, Hong et al cited that as many as 35% of their reviewed patients had lesions detected at MRI and were then treated with breast conservation therapy
rather than total mastectomy.
A variety of patient, treatment, and pathologic factors are associated with an increased risk of ipsilateral breast tumor recurrence (local recurrence) after breast conservation therapy
for invasive breast cancer.
Surgical treatment for breast cancer includes breast conservation therapy
and mastectomy with or without axillary dissection depending on disease stage.
The many refinements in breast conservation therapy
have resulted in greatly improved treatment.
Modern, randomized trials investigating breast conservation therapy
(BCT) for early-stage breast cancer have shown that radiotherapy (RT) cannot be omitted in any subgroup of breast cancer patients without compromising local control [1-3].
An additional challenge is the lack of frozen-section procedure for the assessment of tumour-free margins, with the result that breast conservation therapy
is hardly possible.
"Accelerated Partial Breast Irradiation as a Part of Breast Conservation Therapy
." Journal of Clinical Oncology 23 (8): 1726.
The study specifically focused on patients with tumours that were [less than or equal to] 2 cm (n=319) who either had a mastectomy (n=55) or breast conservation therapy
In addition, the number of disease foci can determine whether or not breast conservation therapy
should be considered.